Alterations in purine and pyrimidine metabolism associated with latent tuberculosis infection: insights from gut microbiome and metabolomics analyses

Alterations in purine and pyrimidine metabolism associated with latent tuberculosis infection: insights from gut microbiome and metabolomics analyses

ABSTRACT Individuals with latent tuberculosis infection (LTBI) account for almost 30% of the population worldwide and have the potential to develop active tuberculosis (ATB). Despite this, the current understanding of the pathogenesis of LTBI is limited. The gut microbiome can be altered in tubercul...

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Bibliographic Details
Main Authors: Boyi Yang, Xiaojing Guo, Chongyu Shi, Gang Liu, Xiaoling Qin, Shiyi Chen, Li Gan, Dongxu Liang, Kai Shao, Ruolan Xu, Jieqing Zhong, Yujie Mo, Hai Li, Dan Luo
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mSystems
Subjects:
latent tuberculosis infection
active tuberculosis
gut microbiome
metabolomics
purine metabolism
pyrimidine metabolism
Online Access:https://journals.asm.org/doi/10.1128/msystems.00812-24
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