Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China
Objective. To explore the clinical characteristics of patients with different severity in the early outbreak of COVID-19, hoping to provide reference for clinical diagnosis and treatment. Methods. We retrospectively analyzed the clinical data of 95 COVID-19 patients in Wuhan Red Cross Hospital of Ch...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/4783062 |
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| author | Fang He Xue-feng Ding Meng Cao Hai-ying Gong Xiang-zhen Fu Jie Luo Kui Liu Zhou-zhou Tian Lin Luo Yu-yuan Fan Ting Li Qian-Jing Yao Xiao-ju Chen Xiang-lin Duan Li Chen Li Jiang |
| author_facet | Fang He Xue-feng Ding Meng Cao Hai-ying Gong Xiang-zhen Fu Jie Luo Kui Liu Zhou-zhou Tian Lin Luo Yu-yuan Fan Ting Li Qian-Jing Yao Xiao-ju Chen Xiang-lin Duan Li Chen Li Jiang |
| author_sort | Fang He |
| collection | DOAJ |
| description | Objective. To explore the clinical characteristics of patients with different severity in the early outbreak of COVID-19, hoping to provide reference for clinical diagnosis and treatment. Methods. We retrospectively analyzed the clinical data of 95 COVID-19 patients in Wuhan Red Cross Hospital of China from January 17 to February 13, 2020. All patients were investigated with epidemiological questionnaires. Outcomes were followed up until April 1, 2020. Results. There were 53 males and 42 females, aged 22–84 years (mean 57.3 years). Clinical classification included 54 cases of common type, 27 cases of severe type, and 14 cases of critical type. Six patients had been exposed to the local Huanan seafood market. There were 38 clusters of COVID-19, including 27 family clusters and 11 work unit clusters. Common symptoms included fever (86 (90.5%) of 95), cough (73 (76.8%)), and fatigue (50 (52.6%)). Laboratory findings showed that the most common abnormalities were lymphopenia (75 (78.9%)), elevated D-dimer (60 (63.2%)), and elevated C-reactive protein (56 (58.9%)) on admission. All patients had abnormal chest computed tomography, showing patchy shadows or ground-glass opacities. Severe and critical cases were older, more likely to have shortness of breath, more likely to have underlying comorbidities, and more likely to have abnormal laboratory findings than common cases. The prognosis of patients with different degrees of severity was significantly different. All common and severe patients (100%) were cured and discharged from the hospital, while 10 (71.4%) of 14 critical patients died. Conclusions. COVID-19 has fast transmission speed and high pathogenicity. We must assess the severity of the disease and take corresponding treatment measures as early as possible. |
| format | Article |
| id | doaj-art-862882a60f984bc6b195ec0b69fe920a |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-862882a60f984bc6b195ec0b69fe920a2025-02-03T06:46:59ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/47830624783062Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, ChinaFang He0Xue-feng Ding1Meng Cao2Hai-ying Gong3Xiang-zhen Fu4Jie Luo5Kui Liu6Zhou-zhou Tian7Lin Luo8Yu-yuan Fan9Ting Li10Qian-Jing Yao11Xiao-ju Chen12Xiang-lin Duan13Li Chen14Li Jiang15Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Medical Intensive Care Unit, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Infectious Disease, The First People’s Hospital of Yibin, Yibin, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaDepartment of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Orthopedics, Wuhan Red Cross Hospital, Wuhan, ChinaDepartment of Medical Intensive Care Unit, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaObjective. To explore the clinical characteristics of patients with different severity in the early outbreak of COVID-19, hoping to provide reference for clinical diagnosis and treatment. Methods. We retrospectively analyzed the clinical data of 95 COVID-19 patients in Wuhan Red Cross Hospital of China from January 17 to February 13, 2020. All patients were investigated with epidemiological questionnaires. Outcomes were followed up until April 1, 2020. Results. There were 53 males and 42 females, aged 22–84 years (mean 57.3 years). Clinical classification included 54 cases of common type, 27 cases of severe type, and 14 cases of critical type. Six patients had been exposed to the local Huanan seafood market. There were 38 clusters of COVID-19, including 27 family clusters and 11 work unit clusters. Common symptoms included fever (86 (90.5%) of 95), cough (73 (76.8%)), and fatigue (50 (52.6%)). Laboratory findings showed that the most common abnormalities were lymphopenia (75 (78.9%)), elevated D-dimer (60 (63.2%)), and elevated C-reactive protein (56 (58.9%)) on admission. All patients had abnormal chest computed tomography, showing patchy shadows or ground-glass opacities. Severe and critical cases were older, more likely to have shortness of breath, more likely to have underlying comorbidities, and more likely to have abnormal laboratory findings than common cases. The prognosis of patients with different degrees of severity was significantly different. All common and severe patients (100%) were cured and discharged from the hospital, while 10 (71.4%) of 14 critical patients died. Conclusions. COVID-19 has fast transmission speed and high pathogenicity. We must assess the severity of the disease and take corresponding treatment measures as early as possible.http://dx.doi.org/10.1155/2020/4783062 |
| spellingShingle | Fang He Xue-feng Ding Meng Cao Hai-ying Gong Xiang-zhen Fu Jie Luo Kui Liu Zhou-zhou Tian Lin Luo Yu-yuan Fan Ting Li Qian-Jing Yao Xiao-ju Chen Xiang-lin Duan Li Chen Li Jiang Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China |
| title_full | Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China |
| title_fullStr | Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China |
| title_full_unstemmed | Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China |
| title_short | Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China |
| title_sort | comparative analysis of 95 patients with different severity in the early outbreak of covid 19 in wuhan china |
| url | http://dx.doi.org/10.1155/2020/4783062 |
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