Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital
Objective: To assess the changes in high sensitivity C Reactive protein (hs-CRP), serum cholesterol, uric acid, creatinine, bilirubin and ALT in patients of primary open angle glaucoma. Material and methods: Comparative cross-sectional study conducted between April 2021 and October 2021 at depar...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Rawalpindi Medical University
2022-12-01
|
| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/1996 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832086952457797632 |
|---|---|
| author | Fatima Tuz Zuhra Mehnaz Khattak Sana Nadeem Noreen Atzaz Attika Khalid Sami Saeed |
| author_facet | Fatima Tuz Zuhra Mehnaz Khattak Sana Nadeem Noreen Atzaz Attika Khalid Sami Saeed |
| author_sort | Fatima Tuz Zuhra |
| collection | DOAJ |
| description |
Objective: To assess the changes in high sensitivity C Reactive protein (hs-CRP), serum cholesterol, uric acid, creatinine, bilirubin and ALT in patients of primary open angle glaucoma.
Material and methods: Comparative cross-sectional study conducted between April 2021 and October 2021 at departments of Ophthalmology and Pathology, --removed for blind review----44 POAG patients and 54 healthy controls volunteered to participate in the study. POAG was diagnosed as per criteria. Venous blood was drawn for analysis of serum cholesterol, uric acid, creatinine, bilirubin, ALT and hs-CRP. hs-CRP was performed on ELISA plate reader Platos R496 while spectrophotometric analysis of serum uric acid, creatinine, and cholesterol was carried on Beckman Coulter AU-700.
Results: Mean hemoglobin (Hb), Total leukocyte count (TLC), serum urea, creatinine, uric acid, ALT, bilirubin, cholesterol and HbA1c were 12.80 ±1.50g, 8.88±1.92 mm3, 5.95±5.47 µmol/l, 92.19±21.81 µmol/l, 305.85±79.92 mmol/l, 34.31±18.26 IU/L, 9.26±3.11 µmol/l, 5.18±0.96 mmol/l,6.70±1.28 %respectively whereas the Mean IOP in POAG patients was 28mmHg, mean CCT was 516.6 µm, and mean vertical CDR was 0.6.
High frequency of hs-CRP positivity (50 percent) was reported in our patients. Significantly lower uric acid levels were observed in primary open angle glaucoma patients versus controls ie 305.85±79.92 mmol/l vs 344.36±37.24 mmol/l (P value < 0.05). Serum creatinine was significantly different between mild and severe groups i.e. 88±14.7 vs 113.1±32.4. (p value <0.001*)
Conclusion: High frequency of hs-CRP positivity and low uric acid levels suggest the presence of para inflammation in patients of POAG.
Key words:
Primary open angle glaucoma (POAG), intraocular pressure (IOP), high sensitivity CRP (hs-CRP), uric acid (UA)
|
| format | Article |
| id | doaj-art-8624052dd1164d558b086bda356b3432 |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-8624052dd1164d558b086bda356b34322025-02-06T08:45:18ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702022-12-0126410.37939/jrmc.v26i4.1996Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospitalFatima Tuz ZuhraMehnaz KhattakSana NadeemNoreen AtzazAttika KhalidSami Saeed Objective: To assess the changes in high sensitivity C Reactive protein (hs-CRP), serum cholesterol, uric acid, creatinine, bilirubin and ALT in patients of primary open angle glaucoma. Material and methods: Comparative cross-sectional study conducted between April 2021 and October 2021 at departments of Ophthalmology and Pathology, --removed for blind review----44 POAG patients and 54 healthy controls volunteered to participate in the study. POAG was diagnosed as per criteria. Venous blood was drawn for analysis of serum cholesterol, uric acid, creatinine, bilirubin, ALT and hs-CRP. hs-CRP was performed on ELISA plate reader Platos R496 while spectrophotometric analysis of serum uric acid, creatinine, and cholesterol was carried on Beckman Coulter AU-700. Results: Mean hemoglobin (Hb), Total leukocyte count (TLC), serum urea, creatinine, uric acid, ALT, bilirubin, cholesterol and HbA1c were 12.80 ±1.50g, 8.88±1.92 mm3, 5.95±5.47 µmol/l, 92.19±21.81 µmol/l, 305.85±79.92 mmol/l, 34.31±18.26 IU/L, 9.26±3.11 µmol/l, 5.18±0.96 mmol/l,6.70±1.28 %respectively whereas the Mean IOP in POAG patients was 28mmHg, mean CCT was 516.6 µm, and mean vertical CDR was 0.6. High frequency of hs-CRP positivity (50 percent) was reported in our patients. Significantly lower uric acid levels were observed in primary open angle glaucoma patients versus controls ie 305.85±79.92 mmol/l vs 344.36±37.24 mmol/l (P value < 0.05). Serum creatinine was significantly different between mild and severe groups i.e. 88±14.7 vs 113.1±32.4. (p value <0.001*) Conclusion: High frequency of hs-CRP positivity and low uric acid levels suggest the presence of para inflammation in patients of POAG. Key words: Primary open angle glaucoma (POAG), intraocular pressure (IOP), high sensitivity CRP (hs-CRP), uric acid (UA) https://www.journalrmc.com/index.php/JRMC/article/view/1996 |
| spellingShingle | Fatima Tuz Zuhra Mehnaz Khattak Sana Nadeem Noreen Atzaz Attika Khalid Sami Saeed Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital Journal of Rawalpindi Medical College |
| title | Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital |
| title_full | Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital |
| title_fullStr | Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital |
| title_full_unstemmed | Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital |
| title_short | Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital |
| title_sort | assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/1996 |
| work_keys_str_mv | AT fatimatuzzuhra assessmentofderangementinbiochemicalprofileinprimaryopenangleglaucomapatientspresentingatatertiarycarehospital AT mehnazkhattak assessmentofderangementinbiochemicalprofileinprimaryopenangleglaucomapatientspresentingatatertiarycarehospital AT sananadeem assessmentofderangementinbiochemicalprofileinprimaryopenangleglaucomapatientspresentingatatertiarycarehospital AT noreenatzaz assessmentofderangementinbiochemicalprofileinprimaryopenangleglaucomapatientspresentingatatertiarycarehospital AT attikakhalid assessmentofderangementinbiochemicalprofileinprimaryopenangleglaucomapatientspresentingatatertiarycarehospital AT samisaeed assessmentofderangementinbiochemicalprofileinprimaryopenangleglaucomapatientspresentingatatertiarycarehospital |