Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration
The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/8490489 |
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| _version_ | 1832559085053018112 |
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| author | Yoojun Nam Yeri Alice Rim Jennifer Lee Ji Hyeon Ju |
| author_facet | Yoojun Nam Yeri Alice Rim Jennifer Lee Ji Hyeon Ju |
| author_sort | Yoojun Nam |
| collection | DOAJ |
| description | The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues. Cartilage may be an ideal target for stem cell treatment because it has a notoriously poor regenerative potential. In this review, we describe past, present, and future strategies to regenerate cartilage in patients. Specifically, this review compares a surgical regenerative technique (microfracture) and cell therapy, cell therapy with and without a scaffold, and therapy with nonaggregated and aggregated cells. We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells. |
| format | Article |
| id | doaj-art-8622c9c517ed41f49aab74a3fb65b924 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8622c9c517ed41f49aab74a3fb65b9242025-02-03T01:30:53ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/84904898490489Current Therapeutic Strategies for Stem Cell-Based Cartilage RegenerationYoojun Nam0Yeri Alice Rim1Jennifer Lee2Ji Hyeon Ju3CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaCiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaCiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaCiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaThe process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues. Cartilage may be an ideal target for stem cell treatment because it has a notoriously poor regenerative potential. In this review, we describe past, present, and future strategies to regenerate cartilage in patients. Specifically, this review compares a surgical regenerative technique (microfracture) and cell therapy, cell therapy with and without a scaffold, and therapy with nonaggregated and aggregated cells. We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells.http://dx.doi.org/10.1155/2018/8490489 |
| spellingShingle | Yoojun Nam Yeri Alice Rim Jennifer Lee Ji Hyeon Ju Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration Stem Cells International |
| title | Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration |
| title_full | Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration |
| title_fullStr | Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration |
| title_full_unstemmed | Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration |
| title_short | Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration |
| title_sort | current therapeutic strategies for stem cell based cartilage regeneration |
| url | http://dx.doi.org/10.1155/2018/8490489 |
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