Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients
Background: To study the risk of cardiovascular disease (CVD) and other competing causes of death in older kidney cancer patients. Methods: Data on older patients (aged 65 and above) diagnosed with kidney cancer...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25277 |
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| author | Yinglan Liang Liangjia Zeng Ruoyun Zhou Manting Feng Linglong Liu Kexin Chen Jinqi Huang Haowen Liang Baixin He Binghua Zhang Yican Ying Yuerong Chen Tianwang Guan Min Yi |
| author_facet | Yinglan Liang Liangjia Zeng Ruoyun Zhou Manting Feng Linglong Liu Kexin Chen Jinqi Huang Haowen Liang Baixin He Binghua Zhang Yican Ying Yuerong Chen Tianwang Guan Min Yi |
| author_sort | Yinglan Liang |
| collection | DOAJ |
| description | Background: To study the risk of cardiovascular disease (CVD) and other competing causes of death in older kidney cancer patients. Methods: Data on older patients (aged 65 and above) diagnosed with kidney cancer between 1975 and 2018 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We delved into the distribution of CVD and other competing causes of death across the entire cohort and in various patient subgroups. The competing risk analysis was used to produce cumulative mortality curves based on cumulative mortality for the primary outcomes by follow-up period. Utilizing the standardized mortality ratios (SMRs) and absolute excess risks (AERs), we contrasted the risk of CVD and other competing causes of death in older kidney cancer patients to that observed in the general population. Results: The analysis included 29,349 older kidney cancer patients, of which included 4563 CVD deaths. As survival time extended, the proportion of non-cancer deaths increased in older kidney cancer patients, with CVD accounting for the largest share of non-cancer deaths. At 10–15 years after diagnosis, cumulative non-cancer mortality exceeded primary kidney cancer as the predominant cause of death, and cumulative CVD mortality is higher among all non-cancer causes. Older kidney cancer patients exhibited a greater risk of CVD and other non-cancer deaths than their counterparts in the general older population did (SMR: 1.38–2.81; AER: 1.1–143.69). Conclusions: As survival time increases, the risk of non-cancer death in older kidney cancer patients gradually surpassed that of primary cancer, and CVD death accounted for the majority of non-cancer deaths. Among older kidney cancer patients, the risk of CVD mortality was higher than in the general population. Managing non-cancer deaths, especially CVD deaths, should be a focus in the care of older kidney cancer patients. |
| format | Article |
| id | doaj-art-86050a264d344c96955d11d3a1fc45b6 |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-86050a264d344c96955d11d3a1fc45b62025-01-25T10:41:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612527710.31083/RCM25277S1530-6550(24)01591-6Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer PatientsYinglan Liang0Liangjia Zeng1Ruoyun Zhou2Manting Feng3Linglong Liu4Kexin Chen5Jinqi Huang6Haowen Liang7Baixin He8Binghua Zhang9Yican Ying10Yuerong Chen11Tianwang Guan12Min Yi13Department of Anesthesiology, The Second Clinical College of Guangzhou Medical University, 510180 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaDepartment of Anesthesiology, The Second Clinical College of Guangzhou Medical University, 510180 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaCardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, 510000 Guangzhou, Guangdong, ChinaMinimally Invasive Tumor Therapies Center, Guangdong Second Provincial General Hospital, 510317 Guangzhou, Guangdong, ChinaGuangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, Cancer Center, the 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou 510280, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, Guangdong, ChinaBackground: To study the risk of cardiovascular disease (CVD) and other competing causes of death in older kidney cancer patients. Methods: Data on older patients (aged 65 and above) diagnosed with kidney cancer between 1975 and 2018 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We delved into the distribution of CVD and other competing causes of death across the entire cohort and in various patient subgroups. The competing risk analysis was used to produce cumulative mortality curves based on cumulative mortality for the primary outcomes by follow-up period. Utilizing the standardized mortality ratios (SMRs) and absolute excess risks (AERs), we contrasted the risk of CVD and other competing causes of death in older kidney cancer patients to that observed in the general population. Results: The analysis included 29,349 older kidney cancer patients, of which included 4563 CVD deaths. As survival time extended, the proportion of non-cancer deaths increased in older kidney cancer patients, with CVD accounting for the largest share of non-cancer deaths. At 10–15 years after diagnosis, cumulative non-cancer mortality exceeded primary kidney cancer as the predominant cause of death, and cumulative CVD mortality is higher among all non-cancer causes. Older kidney cancer patients exhibited a greater risk of CVD and other non-cancer deaths than their counterparts in the general older population did (SMR: 1.38–2.81; AER: 1.1–143.69). Conclusions: As survival time increases, the risk of non-cancer death in older kidney cancer patients gradually surpassed that of primary cancer, and CVD death accounted for the majority of non-cancer deaths. Among older kidney cancer patients, the risk of CVD mortality was higher than in the general population. Managing non-cancer deaths, especially CVD deaths, should be a focus in the care of older kidney cancer patients.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25277kidney cancerolder patientscause of deathcardiovascular disease deathcardio-oncology |
| spellingShingle | Yinglan Liang Liangjia Zeng Ruoyun Zhou Manting Feng Linglong Liu Kexin Chen Jinqi Huang Haowen Liang Baixin He Binghua Zhang Yican Ying Yuerong Chen Tianwang Guan Min Yi Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients Reviews in Cardiovascular Medicine kidney cancer older patients cause of death cardiovascular disease death cardio-oncology |
| title | Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients |
| title_full | Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients |
| title_fullStr | Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients |
| title_full_unstemmed | Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients |
| title_short | Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients |
| title_sort | cardiovascular disease and other competing causes of death in older kidney cancer patients |
| topic | kidney cancer older patients cause of death cardiovascular disease death cardio-oncology |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25277 |
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