Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy
The gut-brain axis concept has become an exciting area of research in psychiatry. Gastrointestinal inflammation and gut microbiome dysbiosis have been associated with mental health disorders. Obsessive-compulsive disorder (OCD) is a debilitating and complex mental illness that cannot be completely...
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| Format: | Article |
| Language: | English |
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HH Publisher
2022-11-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/669 |
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| author | Grace Yong-En Kong Vengadesh Letchumanan Loh Teng-Hern Tan Jodi Woan-Fei Law |
| author_facet | Grace Yong-En Kong Vengadesh Letchumanan Loh Teng-Hern Tan Jodi Woan-Fei Law |
| author_sort | Grace Yong-En Kong |
| collection | DOAJ |
| description |
The gut-brain axis concept has become an exciting area of research in psychiatry. Gastrointestinal inflammation and gut microbiome dysbiosis have been associated with mental health disorders. Obsessive-compulsive disorder (OCD) is a debilitating and complex mental illness that cannot be completely curable, stemming from many causes and risk factors. Generally, there is limited research on OCD and its association with the gut microbiome compared to other psychiatric conditions such as depression and anxiety. This review aims to provide insights into the association of gut microbiome and gastrointestinal inflammation with OCD. Besides, the role of probiotics as a potential therapy will be discussed in this review. The studies compiled in this review demonstrated variations in the gut microbial composition, often with lower microbial diversity in OCD patients compared to the controls. The gut microbiome is also involved in regulating the immune system. Alteration in certain groups of gut bacteria could give rise to inflammation and manifestations of gastrointestinal symptoms in OCD patients. As an approach to restoring the balance of the gut microbiome, probiotics serve as an effective solution. In vivo animal studies showed that probiotics can potentially improve OCD symptoms. Nevertheless, clinical trials are required to determine the efficacy of probiotics as an adjuvant therapy to alleviate OCD symptoms.
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| format | Article |
| id | doaj-art-8601a120be304f9c88a6c452848a13e7 |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-8601a120be304f9c88a6c452848a13e72025-02-04T08:40:03ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492022-11-015110.36877/pmmb.a0000272Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant TherapyGrace Yong-En KongVengadesh LetchumananLoh Teng-Hern TanJodi Woan-Fei Law The gut-brain axis concept has become an exciting area of research in psychiatry. Gastrointestinal inflammation and gut microbiome dysbiosis have been associated with mental health disorders. Obsessive-compulsive disorder (OCD) is a debilitating and complex mental illness that cannot be completely curable, stemming from many causes and risk factors. Generally, there is limited research on OCD and its association with the gut microbiome compared to other psychiatric conditions such as depression and anxiety. This review aims to provide insights into the association of gut microbiome and gastrointestinal inflammation with OCD. Besides, the role of probiotics as a potential therapy will be discussed in this review. The studies compiled in this review demonstrated variations in the gut microbial composition, often with lower microbial diversity in OCD patients compared to the controls. The gut microbiome is also involved in regulating the immune system. Alteration in certain groups of gut bacteria could give rise to inflammation and manifestations of gastrointestinal symptoms in OCD patients. As an approach to restoring the balance of the gut microbiome, probiotics serve as an effective solution. In vivo animal studies showed that probiotics can potentially improve OCD symptoms. Nevertheless, clinical trials are required to determine the efficacy of probiotics as an adjuvant therapy to alleviate OCD symptoms. https://journals.hh-publisher.com/index.php/pmmb/article/view/669 |
| spellingShingle | Grace Yong-En Kong Vengadesh Letchumanan Loh Teng-Hern Tan Jodi Woan-Fei Law Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy Progress in Microbes and Molecular Biology |
| title | Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy |
| title_full | Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy |
| title_fullStr | Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy |
| title_full_unstemmed | Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy |
| title_short | Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy |
| title_sort | gut microbiome in obsessive compulsive disorder potential of probiotics as an adjuvant therapy |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/669 |
| work_keys_str_mv | AT graceyongenkong gutmicrobiomeinobsessivecompulsivedisorderpotentialofprobioticsasanadjuvanttherapy AT vengadeshletchumanan gutmicrobiomeinobsessivecompulsivedisorderpotentialofprobioticsasanadjuvanttherapy AT lohtengherntan gutmicrobiomeinobsessivecompulsivedisorderpotentialofprobioticsasanadjuvanttherapy AT jodiwoanfeilaw gutmicrobiomeinobsessivecompulsivedisorderpotentialofprobioticsasanadjuvanttherapy |