Interplay between Extracellular Matrix and Neutrophils in Diseases
The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differentiation, proliferation, and migration. Neutrophi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8243378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556901312757760 |
|---|---|
| author | Yanyan Zhu Yumeng Huang Qian Ji Shengqiao Fu Jia Gu Ningzheng Tai Xu Wang |
| author_facet | Yanyan Zhu Yumeng Huang Qian Ji Shengqiao Fu Jia Gu Ningzheng Tai Xu Wang |
| author_sort | Yanyan Zhu |
| collection | DOAJ |
| description | The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differentiation, proliferation, and migration. Neutrophils are the most abundant immune cells in circulation and play key roles in orchestrating a complex series of events during inflammation. Neutrophils can also mediate ECM remodeling by providing specific matrix-remodeling enzymes (such as neutrophil elastase and metalloproteinases), generating neutrophil extracellular traps, and releasing exosomes. In turn, ECM can remodel the inflammatory microenvironment by regulating the function of neutrophils, which drives disease progression. Both the presence of ECM and the interplay between neutrophils and their extracellular matrices are considered an important and outstanding mechanistic aspect of inflammation. In this review, the importance of ECM will be considered, together with the discussion of recent advances in understanding the underlying mechanisms of the intricate interplay between ECM and neutrophils. A better comprehension of immune cell-matrix reciprocal dependence has exciting implications for the development of new therapeutic options for neutrophil-associated infectious and inflammatory diseases. |
| format | Article |
| id | doaj-art-85fa5b022a464088aaf4d45448b3002a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-85fa5b022a464088aaf4d45448b3002a2025-02-03T05:44:08ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/82433788243378Interplay between Extracellular Matrix and Neutrophils in DiseasesYanyan Zhu0Yumeng Huang1Qian Ji2Shengqiao Fu3Jia Gu4Ningzheng Tai5Xu Wang6Department of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaDepartment of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaDepartment of Radiation Oncology, Institute of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaDepartment of Radiation Oncology, Institute of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaDepartment of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaDepartment of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaDepartment of Radiation Oncology, Institute of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001 Jiangsu Province, ChinaThe extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differentiation, proliferation, and migration. Neutrophils are the most abundant immune cells in circulation and play key roles in orchestrating a complex series of events during inflammation. Neutrophils can also mediate ECM remodeling by providing specific matrix-remodeling enzymes (such as neutrophil elastase and metalloproteinases), generating neutrophil extracellular traps, and releasing exosomes. In turn, ECM can remodel the inflammatory microenvironment by regulating the function of neutrophils, which drives disease progression. Both the presence of ECM and the interplay between neutrophils and their extracellular matrices are considered an important and outstanding mechanistic aspect of inflammation. In this review, the importance of ECM will be considered, together with the discussion of recent advances in understanding the underlying mechanisms of the intricate interplay between ECM and neutrophils. A better comprehension of immune cell-matrix reciprocal dependence has exciting implications for the development of new therapeutic options for neutrophil-associated infectious and inflammatory diseases.http://dx.doi.org/10.1155/2021/8243378 |
| spellingShingle | Yanyan Zhu Yumeng Huang Qian Ji Shengqiao Fu Jia Gu Ningzheng Tai Xu Wang Interplay between Extracellular Matrix and Neutrophils in Diseases Journal of Immunology Research |
| title | Interplay between Extracellular Matrix and Neutrophils in Diseases |
| title_full | Interplay between Extracellular Matrix and Neutrophils in Diseases |
| title_fullStr | Interplay between Extracellular Matrix and Neutrophils in Diseases |
| title_full_unstemmed | Interplay between Extracellular Matrix and Neutrophils in Diseases |
| title_short | Interplay between Extracellular Matrix and Neutrophils in Diseases |
| title_sort | interplay between extracellular matrix and neutrophils in diseases |
| url | http://dx.doi.org/10.1155/2021/8243378 |
| work_keys_str_mv | AT yanyanzhu interplaybetweenextracellularmatrixandneutrophilsindiseases AT yumenghuang interplaybetweenextracellularmatrixandneutrophilsindiseases AT qianji interplaybetweenextracellularmatrixandneutrophilsindiseases AT shengqiaofu interplaybetweenextracellularmatrixandneutrophilsindiseases AT jiagu interplaybetweenextracellularmatrixandneutrophilsindiseases AT ningzhengtai interplaybetweenextracellularmatrixandneutrophilsindiseases AT xuwang interplaybetweenextracellularmatrixandneutrophilsindiseases |