NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus
Aims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role o...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7526919 |
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| author | Nektaria Papadopoulou-Marketou Alexandra Margeli Ioannis Papassotiriou George P. Chrousos Christina Kanaka-Gantenbein Jeanette Wahlberg |
| author_facet | Nektaria Papadopoulou-Marketou Alexandra Margeli Ioannis Papassotiriou George P. Chrousos Christina Kanaka-Gantenbein Jeanette Wahlberg |
| author_sort | Nektaria Papadopoulou-Marketou |
| collection | DOAJ |
| description | Aims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. Methods. Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). Results. NGAL correlated positively with SAP in both patient groups (P=0.020 and P=0.031, resp.) and SAP z-score (P=0.009) (group A) and negatively with eGFR in both groups (P<0.001 and P<0.001, resp.). Conclusions. NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range. |
| format | Article |
| id | doaj-art-85f923754e6540a78fa17c97da96c26e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-85f923754e6540a78fa17c97da96c26e2025-02-03T07:25:23ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/75269197526919NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes MellitusNektaria Papadopoulou-Marketou0Alexandra Margeli1Ioannis Papassotiriou2George P. Chrousos3Christina Kanaka-Gantenbein4Jeanette Wahlberg5Department of Endocrinology, Department of Medical and Health Sciences, Linkoping University, Linkoping, SwedenDepartment of Clinical Biochemistry, Aghia Sophia Children’s Hospital, Athens, GreeceDepartment of Clinical Biochemistry, Aghia Sophia Children’s Hospital, Athens, GreeceDiabetes Centre, Department of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, Athens, GreeceDiabetes Centre, Department of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, Athens, GreeceDepartment of Endocrinology, Department of Medical and Health Sciences, Linkoping University, Linkoping, SwedenAims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. Methods. Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). Results. NGAL correlated positively with SAP in both patient groups (P=0.020 and P=0.031, resp.) and SAP z-score (P=0.009) (group A) and negatively with eGFR in both groups (P<0.001 and P<0.001, resp.). Conclusions. NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range.http://dx.doi.org/10.1155/2017/7526919 |
| spellingShingle | Nektaria Papadopoulou-Marketou Alexandra Margeli Ioannis Papassotiriou George P. Chrousos Christina Kanaka-Gantenbein Jeanette Wahlberg NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus Journal of Diabetes Research |
| title | NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus |
| title_full | NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus |
| title_fullStr | NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus |
| title_full_unstemmed | NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus |
| title_short | NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus |
| title_sort | ngal as an early predictive marker of diabetic nephropathy in children and young adults with type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2017/7526919 |
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