NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts
Cholesterol, its derivatives, and metabolites from its biosynthesis are important components of the cell and play an essential role in many intracellular processes, including cell signaling, regulation of the cell cycle, etc. In this paper, it has been shown that depletion of the cholesterol biosynt...
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Kazan Federal University
2015-03-01
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| Series: | Учёные записки Казанского университета: Серия Естественные науки |
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| Online Access: | http://kpfu.ru/portal/docs/F_1335647387/157_1_est_10_e.pdf |
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| _version_ | 1850088000259620864 |
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| author | L.R. Gabitova I.A. Astsaturov |
| author_facet | L.R. Gabitova I.A. Astsaturov |
| author_sort | L.R. Gabitova |
| collection | DOAJ |
| description | Cholesterol, its derivatives, and metabolites from its biosynthesis are important components of the cell and play an essential role in many intracellular processes, including cell signaling, regulation of the cell cycle, etc. In this paper, it has been shown that depletion of the cholesterol biosynthesis pathway enzyme NSDHL (NAD(P)H-dependent steroid dehydrogenase-like) and accumulation of its metabolites lead to an increased rate of cellular senescence and reduction of proliferation in mouse embryonic fibroblasts. The phenomenon described can be useful for developing new strategies of targeting cholesterol biosynthesis pathway in cancer cells in order to increase their senescence and inhibit proliferation. |
| format | Article |
| id | doaj-art-85ecfd8f872b45d08e027b18b0deefa9 |
| institution | DOAJ |
| issn | 1815-6169 2500-218X |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Kazan Federal University |
| record_format | Article |
| series | Учёные записки Казанского университета: Серия Естественные науки |
| spelling | doaj-art-85ecfd8f872b45d08e027b18b0deefa92025-08-20T02:43:06ZengKazan Federal UniversityУчёные записки Казанского университета: Серия Естественные науки1815-61692500-218X2015-03-011571127139NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic FibroblastsL.R. Gabitova0I.A. Astsaturov1Kazan Federal University, Kazan, 420008 Russia; Fox Chase Cancer Center, Philadelphia, PA 19111, USAKazan Federal University, Kazan, 420008 Russia; Fox Chase Cancer Center, Philadelphia, PA 19111, USACholesterol, its derivatives, and metabolites from its biosynthesis are important components of the cell and play an essential role in many intracellular processes, including cell signaling, regulation of the cell cycle, etc. In this paper, it has been shown that depletion of the cholesterol biosynthesis pathway enzyme NSDHL (NAD(P)H-dependent steroid dehydrogenase-like) and accumulation of its metabolites lead to an increased rate of cellular senescence and reduction of proliferation in mouse embryonic fibroblasts. The phenomenon described can be useful for developing new strategies of targeting cholesterol biosynthesis pathway in cancer cells in order to increase their senescence and inhibit proliferation.http://kpfu.ru/portal/docs/F_1335647387/157_1_est_10_e.pdfcholesterolcholesterol biosynthesis pathway metabolitesNAD(P)Н-dependent steroid dehydrogenase-likecellular senescenceinhibition of proliferation |
| spellingShingle | L.R. Gabitova I.A. Astsaturov NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts Учёные записки Казанского университета: Серия Естественные науки cholesterol cholesterol biosynthesis pathway metabolites NAD(P)Н-dependent steroid dehydrogenase-like cellular senescence inhibition of proliferation |
| title | NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts |
| title_full | NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts |
| title_fullStr | NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts |
| title_full_unstemmed | NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts |
| title_short | NSDHL Depletion Promotes Cellular Senescence in Mouse Embryonic Fibroblasts |
| title_sort | nsdhl depletion promotes cellular senescence in mouse embryonic fibroblasts |
| topic | cholesterol cholesterol biosynthesis pathway metabolites NAD(P)Н-dependent steroid dehydrogenase-like cellular senescence inhibition of proliferation |
| url | http://kpfu.ru/portal/docs/F_1335647387/157_1_est_10_e.pdf |
| work_keys_str_mv | AT lrgabitova nsdhldepletionpromotescellularsenescenceinmouseembryonicfibroblasts AT iaastsaturov nsdhldepletionpromotescellularsenescenceinmouseembryonicfibroblasts |