Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis
Abstract Objective Summaries of the relationships between the microbiota and liver cirrhosis and their conclusions are not consistent. This study describes microbial differences in patients with liver cirrhosis by performing a meta-analysis. Methods We searched PubMed, Embase, Web of Science, and th...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03589-5 |
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| author | Ye Liu Ziwei Chen Chang Li Tianhan Sun Xuanmei Luo Boyue Jiang Meilan Liu Qing Wang Tong Li Jianfu Cao Yayu Li Yuan Chen Lu Kuai Fei Xiao Hongtao Xu Hongyuan Cui |
| author_facet | Ye Liu Ziwei Chen Chang Li Tianhan Sun Xuanmei Luo Boyue Jiang Meilan Liu Qing Wang Tong Li Jianfu Cao Yayu Li Yuan Chen Lu Kuai Fei Xiao Hongtao Xu Hongyuan Cui |
| author_sort | Ye Liu |
| collection | DOAJ |
| description | Abstract Objective Summaries of the relationships between the microbiota and liver cirrhosis and their conclusions are not consistent. This study describes microbial differences in patients with liver cirrhosis by performing a meta-analysis. Methods We searched PubMed, Embase, Web of Science, and the Cochrane Library and collected related articles published before March 10, 2024. Ratio of autochthonous to non-autochthonous taxa was calculated as the cirrhosis dysbiosis ratio (CDR). Using a random-effects model, the standard mean deviation (SMD) and 95% confidence interval (CI) were calculated. We subsequently performed subgroup, sensitivity, and publication bias analyses. cirrhosis dysbiosis ratio. Results A total of 53 eligible papers including 5076 participants were included. The pooled estimates revealed a moderately significant reduction in gut microbiome richness in patients with liver cirrhosis compared with controls, including the Shannon, Chao1, observed species, ACE, and PD indices, but no significant difference was observed for the Simpson index. Over 80% of the studies reported significant differences in β diversity. Families Enterobacteriaceae and Pasteurellaceae, belonging to the phylum Proteobacteria, along with the family Streptococcaceae and the genera Haemophilus, Streptococcus, and Veillonella, were significantly associated with liver cirrhosis compared to the control group. In contrast, the healthy group exhibited a higher abundance of the class Clostridia, particularly the families Lachnospiraceae and Ruminococcaceae, which are known for their diversity and role as common gut commensals. Furthermore, the class Bacilli, predominantly represented by the genus Streptococcus, was markedly enriched in the cirrhosis group. Conclusions The microbiota richness of liver cirrhosis patients was lower than that of healthy controls. Alterations in gut microbiota linked to liver cirrhosis were characterized by a decrease in Lachnospiraceae, Ruminococcaceae, and Clostridia and an enrichment of Enterobacteriaceae, Pasteurellaceae, Streptococcaceae, Bacilli, and Streptococcus. |
| format | Article |
| id | doaj-art-85e42923f9f64a7bb2fee1dcab5237f9 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-85e42923f9f64a7bb2fee1dcab5237f92025-01-19T12:25:43ZengBMCBMC Gastroenterology1471-230X2025-01-0125112510.1186/s12876-025-03589-5Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysisYe Liu0Ziwei Chen1Chang Li2Tianhan Sun3Xuanmei Luo4Boyue Jiang5Meilan Liu6Qing Wang7Tong Li8Jianfu Cao9Yayu Li10Yuan Chen11Lu Kuai12Fei Xiao13Hongtao Xu14Hongyuan Cui15Beijing Hospital, Peking University Fifth School of Clinical Medicine, National Center of GerontologyClinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesBeijing Hospital, Peking University Fifth School of Clinical Medicine, National Center of GerontologyDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeClinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeClinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesClinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesClinical Biobank, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesBeijing Hospital, Peking University Fifth School of Clinical Medicine, National Center of GerontologyDepartment of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine , Chinese Academy of Medical Sciences & Peking Union Medical CollegeAbstract Objective Summaries of the relationships between the microbiota and liver cirrhosis and their conclusions are not consistent. This study describes microbial differences in patients with liver cirrhosis by performing a meta-analysis. Methods We searched PubMed, Embase, Web of Science, and the Cochrane Library and collected related articles published before March 10, 2024. Ratio of autochthonous to non-autochthonous taxa was calculated as the cirrhosis dysbiosis ratio (CDR). Using a random-effects model, the standard mean deviation (SMD) and 95% confidence interval (CI) were calculated. We subsequently performed subgroup, sensitivity, and publication bias analyses. cirrhosis dysbiosis ratio. Results A total of 53 eligible papers including 5076 participants were included. The pooled estimates revealed a moderately significant reduction in gut microbiome richness in patients with liver cirrhosis compared with controls, including the Shannon, Chao1, observed species, ACE, and PD indices, but no significant difference was observed for the Simpson index. Over 80% of the studies reported significant differences in β diversity. Families Enterobacteriaceae and Pasteurellaceae, belonging to the phylum Proteobacteria, along with the family Streptococcaceae and the genera Haemophilus, Streptococcus, and Veillonella, were significantly associated with liver cirrhosis compared to the control group. In contrast, the healthy group exhibited a higher abundance of the class Clostridia, particularly the families Lachnospiraceae and Ruminococcaceae, which are known for their diversity and role as common gut commensals. Furthermore, the class Bacilli, predominantly represented by the genus Streptococcus, was markedly enriched in the cirrhosis group. Conclusions The microbiota richness of liver cirrhosis patients was lower than that of healthy controls. Alterations in gut microbiota linked to liver cirrhosis were characterized by a decrease in Lachnospiraceae, Ruminococcaceae, and Clostridia and an enrichment of Enterobacteriaceae, Pasteurellaceae, Streptococcaceae, Bacilli, and Streptococcus.https://doi.org/10.1186/s12876-025-03589-5Liver cirrhosisGut microbiotaIntestinal microbiotaMeta-analysis |
| spellingShingle | Ye Liu Ziwei Chen Chang Li Tianhan Sun Xuanmei Luo Boyue Jiang Meilan Liu Qing Wang Tong Li Jianfu Cao Yayu Li Yuan Chen Lu Kuai Fei Xiao Hongtao Xu Hongyuan Cui Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis BMC Gastroenterology Liver cirrhosis Gut microbiota Intestinal microbiota Meta-analysis |
| title | Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis |
| title_full | Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis |
| title_fullStr | Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis |
| title_full_unstemmed | Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis |
| title_short | Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis |
| title_sort | associations between changes in the gut microbiota and liver cirrhosis a systematic review and meta analysis |
| topic | Liver cirrhosis Gut microbiota Intestinal microbiota Meta-analysis |
| url | https://doi.org/10.1186/s12876-025-03589-5 |
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