Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report
Abstract Background Autoimmune encephalitis associated with anti-GluK2 antibodies is a recently identified condition, typically characterized by cerebellar ataxia. This case report presents a unique clinical manifestation involving involuntary movements and emotional dysregulation, expanding the kno...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-025-04037-3 |
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| author | Zhengping Cheng Yang Song Shuqi Zhao Xiaowen Sui Lili Xie Hongling Zhao Xin Pan Li Cui Xinran Huang Shubei Ma |
| author_facet | Zhengping Cheng Yang Song Shuqi Zhao Xiaowen Sui Lili Xie Hongling Zhao Xin Pan Li Cui Xinran Huang Shubei Ma |
| author_sort | Zhengping Cheng |
| collection | DOAJ |
| description | Abstract Background Autoimmune encephalitis associated with anti-GluK2 antibodies is a recently identified condition, typically characterized by cerebellar ataxia. This case report presents a unique clinical manifestation involving involuntary movements and emotional dysregulation, expanding the known phenotype spectrum. Case presentation A 60-year-old woman presented with a two-year history of involuntary movements predominantly affecting her lower limbs and facial muscles, occasionally accompanied by hysterical shouting. Initial investigations revealed coexisting multiple myeloma (MM) and anti-GluK2 antibody positivity. Following MM-specific therapy, including bortezomib, cyclophosphamide, and dexamethasone, the patient's symptoms resolved, and her serum anti-GluK2 antibody titers decreased significantly. Conclusions This case suggests that involuntary movements and psychiatric symptoms may represent novel phenotypes of anti-GluK2 antibody-associated autoimmune encephalitis. The findings underscore the importance of recognizing the diverse clinical presentations of this rare condition and prompt further research into its underlying mechanisms. |
| format | Article |
| id | doaj-art-85dee44b25f54439b7f068fb1a8d7525 |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-85dee44b25f54439b7f068fb1a8d75252025-01-26T12:39:26ZengBMCBMC Neurology1471-23772025-01-012511410.1186/s12883-025-04037-3Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case reportZhengping Cheng0Yang Song1Shuqi Zhao2Xiaowen Sui3Lili Xie4Hongling Zhao5Xin Pan6Li Cui7Xinran Huang8Shubei Ma9Neurology Department, Central Hospital of Dalian University of TechnologyHematology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyHematology Department, Central Hospital of Dalian University of TechnologyNeurology Department, Central Hospital of Dalian University of TechnologyAbstract Background Autoimmune encephalitis associated with anti-GluK2 antibodies is a recently identified condition, typically characterized by cerebellar ataxia. This case report presents a unique clinical manifestation involving involuntary movements and emotional dysregulation, expanding the known phenotype spectrum. Case presentation A 60-year-old woman presented with a two-year history of involuntary movements predominantly affecting her lower limbs and facial muscles, occasionally accompanied by hysterical shouting. Initial investigations revealed coexisting multiple myeloma (MM) and anti-GluK2 antibody positivity. Following MM-specific therapy, including bortezomib, cyclophosphamide, and dexamethasone, the patient's symptoms resolved, and her serum anti-GluK2 antibody titers decreased significantly. Conclusions This case suggests that involuntary movements and psychiatric symptoms may represent novel phenotypes of anti-GluK2 antibody-associated autoimmune encephalitis. The findings underscore the importance of recognizing the diverse clinical presentations of this rare condition and prompt further research into its underlying mechanisms.https://doi.org/10.1186/s12883-025-04037-3Involuntary movementAlginate-type glutamate receptor subunit 2 (GluK2) encephalitisMultiple myeloma |
| spellingShingle | Zhengping Cheng Yang Song Shuqi Zhao Xiaowen Sui Lili Xie Hongling Zhao Xin Pan Li Cui Xinran Huang Shubei Ma Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report BMC Neurology Involuntary movement Alginate-type glutamate receptor subunit 2 (GluK2) encephalitis Multiple myeloma |
| title | Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report |
| title_full | Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report |
| title_fullStr | Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report |
| title_full_unstemmed | Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report |
| title_short | Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report |
| title_sort | anti gluk2 antibody positive autoimmune encephalitis concurrent with multiple myeloma a case report |
| topic | Involuntary movement Alginate-type glutamate receptor subunit 2 (GluK2) encephalitis Multiple myeloma |
| url | https://doi.org/10.1186/s12883-025-04037-3 |
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