Digestive cancers: mechanisms, therapeutics and management
Abstract Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-024-02097-4 |
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| _version_ | 1832594420477722624 |
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| author | Tianzuo Zhan Johannes Betge Nadine Schulte Lena Dreikhausen Michael Hirth Moying Li Philip Weidner Antonia Leipertz Andreas Teufel Matthias P. Ebert |
| author_facet | Tianzuo Zhan Johannes Betge Nadine Schulte Lena Dreikhausen Michael Hirth Moying Li Philip Weidner Antonia Leipertz Andreas Teufel Matthias P. Ebert |
| author_sort | Tianzuo Zhan |
| collection | DOAJ |
| description | Abstract Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system. This knowledge is continuously translated into novel treatment concepts and targets, which are dynamically reshaping the therapeutic landscape of these tumors. In this review, we provide a concise overview of the etiology and molecular pathology of the six most common cancers of the digestive system, including esophageal, gastric, biliary tract, pancreatic, hepatocellular, and colorectal cancers. We comprehensively describe the current stage-dependent pharmacological management of these malignancies, including chemo-, targeted, and immunotherapy. For each cancer entity, we provide an overview of recent therapeutic advancements and research progress. Finally, we describe how novel insights into tumor heterogeneity and immune evasion deepen our understanding of therapy resistance and provide an outlook on innovative therapeutic strategies that will shape the future management of digestive cancers, including CAR-T cell therapy, novel antibody-drug conjugates and targeted therapies. |
| format | Article |
| id | doaj-art-85dcb3fbe5fa4d55b9d00048bb0da555 |
| institution | Kabale University |
| issn | 2059-3635 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj-art-85dcb3fbe5fa4d55b9d00048bb0da5552025-01-19T12:40:27ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352025-01-0110113910.1038/s41392-024-02097-4Digestive cancers: mechanisms, therapeutics and managementTianzuo Zhan0Johannes Betge1Nadine Schulte2Lena Dreikhausen3Michael Hirth4Moying Li5Philip Weidner6Antonia Leipertz7Andreas Teufel8Matthias P. Ebert9Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityAbstract Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system. This knowledge is continuously translated into novel treatment concepts and targets, which are dynamically reshaping the therapeutic landscape of these tumors. In this review, we provide a concise overview of the etiology and molecular pathology of the six most common cancers of the digestive system, including esophageal, gastric, biliary tract, pancreatic, hepatocellular, and colorectal cancers. We comprehensively describe the current stage-dependent pharmacological management of these malignancies, including chemo-, targeted, and immunotherapy. For each cancer entity, we provide an overview of recent therapeutic advancements and research progress. Finally, we describe how novel insights into tumor heterogeneity and immune evasion deepen our understanding of therapy resistance and provide an outlook on innovative therapeutic strategies that will shape the future management of digestive cancers, including CAR-T cell therapy, novel antibody-drug conjugates and targeted therapies.https://doi.org/10.1038/s41392-024-02097-4 |
| spellingShingle | Tianzuo Zhan Johannes Betge Nadine Schulte Lena Dreikhausen Michael Hirth Moying Li Philip Weidner Antonia Leipertz Andreas Teufel Matthias P. Ebert Digestive cancers: mechanisms, therapeutics and management Signal Transduction and Targeted Therapy |
| title | Digestive cancers: mechanisms, therapeutics and management |
| title_full | Digestive cancers: mechanisms, therapeutics and management |
| title_fullStr | Digestive cancers: mechanisms, therapeutics and management |
| title_full_unstemmed | Digestive cancers: mechanisms, therapeutics and management |
| title_short | Digestive cancers: mechanisms, therapeutics and management |
| title_sort | digestive cancers mechanisms therapeutics and management |
| url | https://doi.org/10.1038/s41392-024-02097-4 |
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