Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance
Background: Systemic inflammation has been associated with lower neurobehavioral performance in diverse populations, yet the evidence in adolescents remains lacking. Cytokines can alter neural network activity to induce neurocognitive changes. This work seeks to investigate the association between i...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266635462400190X |
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| author | Beemnet Amdemicael Kun Yang Briana N.C. Chronister Caroline Mackey Xin Tu Sheila Gahagan Danilo Martinez Harvey Checkoway David R. Jacobs, Jr. Jose Suarez-Torres Suzi Hong Jose R. Suarez-Lopez |
| author_facet | Beemnet Amdemicael Kun Yang Briana N.C. Chronister Caroline Mackey Xin Tu Sheila Gahagan Danilo Martinez Harvey Checkoway David R. Jacobs, Jr. Jose Suarez-Torres Suzi Hong Jose R. Suarez-Lopez |
| author_sort | Beemnet Amdemicael |
| collection | DOAJ |
| description | Background: Systemic inflammation has been associated with lower neurobehavioral performance in diverse populations, yet the evidence in adolescents remains lacking. Cytokines can alter neural network activity to induce neurocognitive changes. This work seeks to investigate the association between inflammation and neurobehavior in adolescents living in a rural region of Ecuador. Methods: We examined 535 adolescents in rural communities of Ecuador (ESPINA study), 508 of which had neurobehavioral assessments (NEPSY-II) and circulating plasma levels of inflammatory markers (CRP, IL-6, TNF-⍺, sICAM-1, sVCAM-1, SAA, and sCD14). Associations between inflammatory biomarker concentrations and neurobehavioral scores were examined using adjusted bivariate semi-parametric models with generalized estimating equations. A partial least squares regression approach was used to create composite variables from multiple inflammation biomarkers and model their association with cognitive outcomes. Results: Higher sCD14 and TNF-α concentrations were significantly associated with lower social perception scores, by −0.465 units (95% CI: −0.80, −0.13) and −0.418 units (−0.72, −0.12) for every 50% increase in inflammatory marker concentration, respectively. Similarly, every 50% increase in the inflammation summary score was associated with a significantly lower Social Perception score by −0.112 units (−0.19, −0.03). A greater inflammatory composite variable from seven markers was associated with lower scores in language (β = −0.11, p = 0.043), visuospatial processing (β = −0.15, p = 0.086), and social perception (β = −0.22, p = 0.005) domains. Conclusions: Higher levels of inflammation were associated with lower neurobehavioral performance in adolescents, especially with social perception. In addition, using a robust analytic method to examine an association between a composite inflammatory variable integrating seven markers led to additional findings, including the domains of language and visuospatial processing. A longitudinal follow-up of such investigations could unveil potential changes in inflammation-neurobehavior performance links through developmental stages and intervention opportunities. |
| format | Article |
| id | doaj-art-85db8f7d2c2946bf9d5a39ad46cb2c12 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-85db8f7d2c2946bf9d5a39ad46cb2c122025-01-26T05:04:59ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-02-0143100912Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevanceBeemnet Amdemicael0Kun Yang1Briana N.C. Chronister2Caroline Mackey3Xin Tu4Sheila Gahagan5Danilo Martinez6Harvey Checkoway7David R. Jacobs, Jr.8Jose Suarez-Torres9Suzi Hong10Jose R. Suarez-Lopez11School of Medicine, University of California, San Diego, 9500 Gilman Drive #0832, La Jolla, CA, 92093-0832, USAHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USAHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USAHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USAHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USADivision of Academic General Pediatrics, Child Development and Community Health, Department of Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive #0832, La Jolla, CA, 92093-0832, USAFundación Cimas Del Ecuador, Quito, Ecuador, De Los Olivos E15-18 y Las Minas, Quito, EcuadorHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USA; Department of Neurosciences, School of Medicine, University of California, San Diego, 9500 Gilman Drive, #0949, La Jolla, CA, 92093-0949, USADivision of Epidemiology, School of Public Health, University of Minnesota, 1300 S 2nd St NE, Suite 300, Minneapolis, MN, 55454, USAFundación Cimas Del Ecuador, Quito, Ecuador, De Los Olivos E15-18 y Las Minas, Quito, EcuadorHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USA; Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0832, La Jolla, CA, 92093-0832, USAHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA, 92024-0725, USA; Corresponding author.Background: Systemic inflammation has been associated with lower neurobehavioral performance in diverse populations, yet the evidence in adolescents remains lacking. Cytokines can alter neural network activity to induce neurocognitive changes. This work seeks to investigate the association between inflammation and neurobehavior in adolescents living in a rural region of Ecuador. Methods: We examined 535 adolescents in rural communities of Ecuador (ESPINA study), 508 of which had neurobehavioral assessments (NEPSY-II) and circulating plasma levels of inflammatory markers (CRP, IL-6, TNF-⍺, sICAM-1, sVCAM-1, SAA, and sCD14). Associations between inflammatory biomarker concentrations and neurobehavioral scores were examined using adjusted bivariate semi-parametric models with generalized estimating equations. A partial least squares regression approach was used to create composite variables from multiple inflammation biomarkers and model their association with cognitive outcomes. Results: Higher sCD14 and TNF-α concentrations were significantly associated with lower social perception scores, by −0.465 units (95% CI: −0.80, −0.13) and −0.418 units (−0.72, −0.12) for every 50% increase in inflammatory marker concentration, respectively. Similarly, every 50% increase in the inflammation summary score was associated with a significantly lower Social Perception score by −0.112 units (−0.19, −0.03). A greater inflammatory composite variable from seven markers was associated with lower scores in language (β = −0.11, p = 0.043), visuospatial processing (β = −0.15, p = 0.086), and social perception (β = −0.22, p = 0.005) domains. Conclusions: Higher levels of inflammation were associated with lower neurobehavioral performance in adolescents, especially with social perception. In addition, using a robust analytic method to examine an association between a composite inflammatory variable integrating seven markers led to additional findings, including the domains of language and visuospatial processing. A longitudinal follow-up of such investigations could unveil potential changes in inflammation-neurobehavior performance links through developmental stages and intervention opportunities.http://www.sciencedirect.com/science/article/pii/S266635462400190XInflammationNeurobehaviorAdolescentsLatin America |
| spellingShingle | Beemnet Amdemicael Kun Yang Briana N.C. Chronister Caroline Mackey Xin Tu Sheila Gahagan Danilo Martinez Harvey Checkoway David R. Jacobs, Jr. Jose Suarez-Torres Suzi Hong Jose R. Suarez-Lopez Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance Brain, Behavior, & Immunity - Health Inflammation Neurobehavior Adolescents Latin America |
| title | Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance |
| title_full | Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance |
| title_fullStr | Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance |
| title_full_unstemmed | Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance |
| title_short | Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance |
| title_sort | inflammation biomarkers and neurobehavioral performance in rural adolescentskey pointsrelevance |
| topic | Inflammation Neurobehavior Adolescents Latin America |
| url | http://www.sciencedirect.com/science/article/pii/S266635462400190X |
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