Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis
In this study, we conducted a systematic review and meta-analysis regarding the role of the neutrophil to lymphocyte ratio (NLR) in Guillain Barré syndrome (GBS). The most recent update to the search was on July 18, 2022, through the databases of Web of Science, PubMed, Embase, and Scopus. The Newca...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/3390831 |
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| author | Shirin Sarejloo Shokoufeh Khanzadeh Samaneh Hosseini Morad Kohandel Gargari Brandon Lucke-Wold Seyedarad Mosalamiaghili Pouria Azami Sanaz Oftadehbalani Shahram Sadeghvand |
| author_facet | Shirin Sarejloo Shokoufeh Khanzadeh Samaneh Hosseini Morad Kohandel Gargari Brandon Lucke-Wold Seyedarad Mosalamiaghili Pouria Azami Sanaz Oftadehbalani Shahram Sadeghvand |
| author_sort | Shirin Sarejloo |
| collection | DOAJ |
| description | In this study, we conducted a systematic review and meta-analysis regarding the role of the neutrophil to lymphocyte ratio (NLR) in Guillain Barré syndrome (GBS). The most recent update to the search was on July 18, 2022, through the databases of Web of Science, PubMed, Embase, and Scopus. The Newcastle-Ottawa scale was used for quality assessment of included studies. Finally, 14 studies were included in the review, and among them, ten studies were included in the meta-analysis. Our results showed that NLR levels were significantly increased in the patients with GBS compared with healthy controls (SMD=1.05; 95%CI=0.59 to 1.50, P<0.001). After treatment, NLR levels were decreased to the extent that they became similar to healthy controls (SMD=−0.03, 95%CI=−0.29 to 0.22, P=0.204). Moreover, NLR was a stable predictor of outcome or response to treatment in such patients (SMD=1.01, 95%CI=0.65 to 1.37, P<0.001); the higher the NLR, the worse the outcome. In addition, patients who underwent mechanical ventilation had higher levels of NLR compared to those who did not (SMD=0.93, 95%CI=0.05 to 1.82, P=0.03). However, NLR levels were not different among distinct GBS subtypes, so it could not distinguish among them. In conclusion, our analysis indicates that the NLR levels are highly elevated in patients with GBS. Therefore, the NLR has the potential to be used as a biomarker to inform diagnosis, prognosis, or treatment responses in GBS, and future studies are warranted. |
| format | Article |
| id | doaj-art-85d6ed356a6248e5b3b08a1dac8c0ae0 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-85d6ed356a6248e5b3b08a1dac8c0ae02025-02-03T06:00:56ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/3390831Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-AnalysisShirin Sarejloo0Shokoufeh Khanzadeh1Samaneh Hosseini2Morad Kohandel Gargari3Brandon Lucke-Wold4Seyedarad Mosalamiaghili5Pouria Azami6Sanaz Oftadehbalani7Shahram Sadeghvand8Cardiovascular Research CenterStudent Research CommitteeNeurosciences Research CenterTabriz University of Medical SciencesUniversity of FloridaStudent Research CommitteeCardiovascular Research CenterFatemeh Zahra HospitalDepartment of PediatricsIn this study, we conducted a systematic review and meta-analysis regarding the role of the neutrophil to lymphocyte ratio (NLR) in Guillain Barré syndrome (GBS). The most recent update to the search was on July 18, 2022, through the databases of Web of Science, PubMed, Embase, and Scopus. The Newcastle-Ottawa scale was used for quality assessment of included studies. Finally, 14 studies were included in the review, and among them, ten studies were included in the meta-analysis. Our results showed that NLR levels were significantly increased in the patients with GBS compared with healthy controls (SMD=1.05; 95%CI=0.59 to 1.50, P<0.001). After treatment, NLR levels were decreased to the extent that they became similar to healthy controls (SMD=−0.03, 95%CI=−0.29 to 0.22, P=0.204). Moreover, NLR was a stable predictor of outcome or response to treatment in such patients (SMD=1.01, 95%CI=0.65 to 1.37, P<0.001); the higher the NLR, the worse the outcome. In addition, patients who underwent mechanical ventilation had higher levels of NLR compared to those who did not (SMD=0.93, 95%CI=0.05 to 1.82, P=0.03). However, NLR levels were not different among distinct GBS subtypes, so it could not distinguish among them. In conclusion, our analysis indicates that the NLR levels are highly elevated in patients with GBS. Therefore, the NLR has the potential to be used as a biomarker to inform diagnosis, prognosis, or treatment responses in GBS, and future studies are warranted.http://dx.doi.org/10.1155/2022/3390831 |
| spellingShingle | Shirin Sarejloo Shokoufeh Khanzadeh Samaneh Hosseini Morad Kohandel Gargari Brandon Lucke-Wold Seyedarad Mosalamiaghili Pouria Azami Sanaz Oftadehbalani Shahram Sadeghvand Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis Mediators of Inflammation |
| title | Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis |
| title_full | Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis |
| title_fullStr | Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis |
| title_short | Role of the Neutrophil to Lymphocyte Ratio in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis |
| title_sort | role of the neutrophil to lymphocyte ratio in guillain barre syndrome a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2022/3390831 |
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