Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults
Background and Aim. Frailty is a geriatric condition resulting from physiological changes covering the musculoskeletal, immune, and neuroendocrine systems, leading to a greater inflammatory state. The present research aimed to investigate the association of components of Fried’s frailty (as well as...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6831791 |
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| author | Gilberto Santos Morais Junior Diego Ignacio Valenzuela Perez Audrey Cecília Tonet-Furioso Lucy Gomes Karla Helena Coelho Vilaça Vicente Paulo Alves Clayton Franco Moraes Otávio Toledo Nóbrega |
| author_facet | Gilberto Santos Morais Junior Diego Ignacio Valenzuela Perez Audrey Cecília Tonet-Furioso Lucy Gomes Karla Helena Coelho Vilaça Vicente Paulo Alves Clayton Franco Moraes Otávio Toledo Nóbrega |
| author_sort | Gilberto Santos Morais Junior |
| collection | DOAJ |
| description | Background and Aim. Frailty is a geriatric condition resulting from physiological changes covering the musculoskeletal, immune, and neuroendocrine systems, leading to a greater inflammatory state. The present research aimed to investigate the association of components of Fried’s frailty (as well as of the phenotype as a whole) with total serum levels of a panel of inflammatory mediators. Methods. One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry. Results. Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08–6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16–7.05; p=0.022). Conclusions. Our study shows a strong negative correlation of IL-6 levels with Fried’s frailty components of grip strength and walk speed in very old adults, regardless of confounding factors. |
| format | Article |
| id | doaj-art-85d5d77889a84858a8c41c0e3563b8b1 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-85d5d77889a84858a8c41c0e3563b8b12025-02-03T06:43:42ZengWileyJournal of Aging Research2090-22042090-22122020-01-01202010.1155/2020/68317916831791Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old AdultsGilberto Santos Morais Junior0Diego Ignacio Valenzuela Perez1Audrey Cecília Tonet-Furioso2Lucy Gomes3Karla Helena Coelho Vilaça4Vicente Paulo Alves5Clayton Franco Moraes6Otávio Toledo Nóbrega7Health Faculty, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, DF, BrazilKinesiology School and Physical Activity and Sports Science Master Program, Universidad Santo Tomás, Puerto Montt, ChileGraduate Program in Gerontology, Campus Taguatinga, Universidade Católica de Brasília, Brasília, DF, BrazilGraduate Program in Gerontology, Campus Taguatinga, Universidade Católica de Brasília, Brasília, DF, BrazilGraduate Program in Gerontology, Campus Taguatinga, Universidade Católica de Brasília, Brasília, DF, BrazilGraduate Program in Gerontology, Campus Taguatinga, Universidade Católica de Brasília, Brasília, DF, BrazilHealth Faculty, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, DF, BrazilHealth Faculty, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, DF, BrazilBackground and Aim. Frailty is a geriatric condition resulting from physiological changes covering the musculoskeletal, immune, and neuroendocrine systems, leading to a greater inflammatory state. The present research aimed to investigate the association of components of Fried’s frailty (as well as of the phenotype as a whole) with total serum levels of a panel of inflammatory mediators. Methods. One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry. Results. Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08–6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16–7.05; p=0.022). Conclusions. Our study shows a strong negative correlation of IL-6 levels with Fried’s frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.http://dx.doi.org/10.1155/2020/6831791 |
| spellingShingle | Gilberto Santos Morais Junior Diego Ignacio Valenzuela Perez Audrey Cecília Tonet-Furioso Lucy Gomes Karla Helena Coelho Vilaça Vicente Paulo Alves Clayton Franco Moraes Otávio Toledo Nóbrega Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults Journal of Aging Research |
| title | Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults |
| title_full | Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults |
| title_fullStr | Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults |
| title_full_unstemmed | Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults |
| title_short | Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults |
| title_sort | circulating interleukin 6 but not other immune mediators associates with criteria for fried s frailty among very old adults |
| url | http://dx.doi.org/10.1155/2020/6831791 |
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