Cytokines in inflammatory bowel disease
Over the past decade, much has been learned regarding the role of various cytokines in the pathogenesis of inflammatory bowel disease. Several cytokine ‘knockout’ models in mice have been shown to develop colitis, while alterations in the production of various cytokines has been documented in human...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791785 |
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| _version_ | 1832562823520059392 |
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| author | P. L. Beck J. L. Wallace |
| author_facet | P. L. Beck J. L. Wallace |
| author_sort | P. L. Beck |
| collection | DOAJ |
| description | Over the past decade, much has been learned regarding the role of various cytokines in the pathogenesis of inflammatory bowel disease. Several cytokine ‘knockout’ models in mice have been shown to develop colitis, while alterations in the production of various cytokines has been documented in human Crohn's disease and ulcerative colitis. In recent years, attempts have been made to treat these diseases through modulation of cytokine production or action. This review focuses on the cytokines that have been implicated in the pathogenesis of inflammatory bowel disease. The evidence for and against a role for particular cytokines in intestinal inflammation is reviewed, as is the experimental and clinical data suggesting that cytokines are rational targets for the development of new therapies. |
| format | Article |
| id | doaj-art-85c4b3146fc64372a9b37cc72557a153 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-85c4b3146fc64372a9b37cc72557a1532025-02-03T01:21:41ZengWileyMediators of Inflammation0962-93511466-18611997-01-01629510310.1080/09629359791785Cytokines in inflammatory bowel diseaseP. L. Beck0J. L. Wallace1Intestinal Disease Research Unit, Departments of Medicine and Pharmacology, University of Calgary, Alberta, Calgary, CanadaIntestinal Disease Research Unit, Departments of Medicine and Pharmacology, University of Calgary, Alberta, Calgary, CanadaOver the past decade, much has been learned regarding the role of various cytokines in the pathogenesis of inflammatory bowel disease. Several cytokine ‘knockout’ models in mice have been shown to develop colitis, while alterations in the production of various cytokines has been documented in human Crohn's disease and ulcerative colitis. In recent years, attempts have been made to treat these diseases through modulation of cytokine production or action. This review focuses on the cytokines that have been implicated in the pathogenesis of inflammatory bowel disease. The evidence for and against a role for particular cytokines in intestinal inflammation is reviewed, as is the experimental and clinical data suggesting that cytokines are rational targets for the development of new therapies.http://dx.doi.org/10.1080/09629359791785 |
| spellingShingle | P. L. Beck J. L. Wallace Cytokines in inflammatory bowel disease Mediators of Inflammation |
| title | Cytokines in inflammatory bowel disease |
| title_full | Cytokines in inflammatory bowel disease |
| title_fullStr | Cytokines in inflammatory bowel disease |
| title_full_unstemmed | Cytokines in inflammatory bowel disease |
| title_short | Cytokines in inflammatory bowel disease |
| title_sort | cytokines in inflammatory bowel disease |
| url | http://dx.doi.org/10.1080/09629359791785 |
| work_keys_str_mv | AT plbeck cytokinesininflammatoryboweldisease AT jlwallace cytokinesininflammatoryboweldisease |