The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388
We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with...
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| Format: | Article |
| Language: | English |
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Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000330 |
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| author | J. Góra-Tybor K. Warzocha T. Robak |
| author_facet | J. Góra-Tybor K. Warzocha T. Robak |
| author_sort | J. Góra-Tybor |
| collection | DOAJ |
| description | We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia L1210 and P388 receiving 2-CdA combined with TNFα had shorter survival times than animals treated with these agents separately. In contrast, the administration of 2-CdA in conjunction with mutein VI, prolonged the survival of mice inoculated with these leukaemias as compared with animals receiving these agents separately. The results of the present study emphasize the importance of the biological activity of the TNFα molecule N-terminus. |
| format | Article |
| id | doaj-art-85c140b475fb48baa297cabc4672eced |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-85c140b475fb48baa297cabc4672eced2025-02-03T01:11:23ZengWileyMediators of Inflammation0962-93511466-18611995-01-014320520810.1155/S0962935195000330The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388J. Góra-Tybor0K. Warzocha1T. Robak2Department of Pharmacology, Medical University of Lódź, Muszyńskiego 1, Lódź 90-150, Poland2nd Department of Internal Medicine, Medical University of Lódź, Pabianicka 62, Lódź 93-513, Poland2nd Department of Internal Medicine, Medical University of Lódź, Pabianicka 62, Lódź 93-513, PolandWe investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia L1210 and P388 receiving 2-CdA combined with TNFα had shorter survival times than animals treated with these agents separately. In contrast, the administration of 2-CdA in conjunction with mutein VI, prolonged the survival of mice inoculated with these leukaemias as compared with animals receiving these agents separately. The results of the present study emphasize the importance of the biological activity of the TNFα molecule N-terminus.http://dx.doi.org/10.1155/S0962935195000330 |
| spellingShingle | J. Góra-Tybor K. Warzocha T. Robak The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 Mediators of Inflammation |
| title | The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 |
| title_full | The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 |
| title_fullStr | The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 |
| title_full_unstemmed | The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 |
| title_short | The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 |
| title_sort | influence of 2 chlorodeoxyadenosine in combination with tumour necrosis factor α or its mutein on murine leukaemias l1210 and p388 |
| url | http://dx.doi.org/10.1155/S0962935195000330 |
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