Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan
Background. Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. Currently, there are limited effective medications approved for this deadly disease. Objective. To inve...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6687412 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567738537607168 |
|---|---|
| author | Ting Zheng Xinxin Liu Yingying Wei Xinlu Li Bing Zheng Quan Gong Lingli Dong Jixin Zhong |
| author_facet | Ting Zheng Xinxin Liu Yingying Wei Xinlu Li Bing Zheng Quan Gong Lingli Dong Jixin Zhong |
| author_sort | Ting Zheng |
| collection | DOAJ |
| description | Background. Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. Currently, there are limited effective medications approved for this deadly disease. Objective. To investigate the potential predictors of COVID-19 mortality and risk factors for hyperinflammation in COVID-19. Methods. Retrospective analysis was carried out in 1,149 patients diagnosed with COVID-19 in Tongji Hospital, Wuhan, China, from 1/13/2020 to 3/15/2020. Results. We found significant differences in the rates of hyperuricemia (OR: 3.17, 95% CI: 2.13-4.70; p<0.001) and hypoalbuminemia (OR: 5.68, 95% CI: 3.97-8.32; p<0.001) between deceased and recovered patients. The percentages of hyperuricemia in deceased patients and recovered patients were 23.6% and 8.9%, respectively, which were higher than the reported age-standardized prevalence of 6.2% in Chinese population. Of note, the percentages of both IL-6 and uric acid levels in survived COVID-19 patients were above 90%, suggesting that they might be good specificity for indicators of mortality in COVID-19 patients. The serum level of uric acid (UA) was positively associated with ferritin, TNF-α, and IL-6 but not with anti-inflammatory cytokine IL-10. In addition, the levels of these proinflammatory cytokines in COVID-19 patients showed a trend of reduction after uric acid lowering therapy. Conclusions. Our results suggest that uric acid, the end product of purine metabolism, was increased in deceased patients with COVID-19. In addition, the serum level of uric acid was positively associated with inflammatory markers. Uric acid lowering therapy in COVID-19 patients with hyperuricemia may be beneficial. |
| format | Article |
| id | doaj-art-85bd072732cd4d79b3e179d16b0da698 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-85bd072732cd4d79b3e179d16b0da6982025-02-03T01:00:41ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/66874126687412Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in WuhanTing Zheng0Xinxin Liu1Yingying Wei2Xinlu Li3Bing Zheng4Quan Gong5Lingli Dong6Jixin Zhong7Department of Immunology, School of Medicine, Yangtze University, Jingzhou, Hubei 434023, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, Hubei 434023, ChinaDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, Hubei 434023, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, ChinaBackground. Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. Currently, there are limited effective medications approved for this deadly disease. Objective. To investigate the potential predictors of COVID-19 mortality and risk factors for hyperinflammation in COVID-19. Methods. Retrospective analysis was carried out in 1,149 patients diagnosed with COVID-19 in Tongji Hospital, Wuhan, China, from 1/13/2020 to 3/15/2020. Results. We found significant differences in the rates of hyperuricemia (OR: 3.17, 95% CI: 2.13-4.70; p<0.001) and hypoalbuminemia (OR: 5.68, 95% CI: 3.97-8.32; p<0.001) between deceased and recovered patients. The percentages of hyperuricemia in deceased patients and recovered patients were 23.6% and 8.9%, respectively, which were higher than the reported age-standardized prevalence of 6.2% in Chinese population. Of note, the percentages of both IL-6 and uric acid levels in survived COVID-19 patients were above 90%, suggesting that they might be good specificity for indicators of mortality in COVID-19 patients. The serum level of uric acid (UA) was positively associated with ferritin, TNF-α, and IL-6 but not with anti-inflammatory cytokine IL-10. In addition, the levels of these proinflammatory cytokines in COVID-19 patients showed a trend of reduction after uric acid lowering therapy. Conclusions. Our results suggest that uric acid, the end product of purine metabolism, was increased in deceased patients with COVID-19. In addition, the serum level of uric acid was positively associated with inflammatory markers. Uric acid lowering therapy in COVID-19 patients with hyperuricemia may be beneficial.http://dx.doi.org/10.1155/2021/6687412 |
| spellingShingle | Ting Zheng Xinxin Liu Yingying Wei Xinlu Li Bing Zheng Quan Gong Lingli Dong Jixin Zhong Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan Mediators of Inflammation |
| title | Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan |
| title_full | Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan |
| title_fullStr | Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan |
| title_full_unstemmed | Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan |
| title_short | Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan |
| title_sort | laboratory predictors of covid 19 mortality a retrospective analysis from tongji hospital in wuhan |
| url | http://dx.doi.org/10.1155/2021/6687412 |
| work_keys_str_mv | AT tingzheng laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT xinxinliu laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT yingyingwei laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT xinluli laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT bingzheng laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT quangong laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT linglidong laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan AT jixinzhong laboratorypredictorsofcovid19mortalityaretrospectiveanalysisfromtongjihospitalinwuhan |