Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility
This review systematically examines the influence of oxidative stress on the reproductive function of male livestock, with a particular focus on the modulation of autophagy. Spermatogenesis, a highly precise biological process, is vulnerable to a range of internal and external factors, among which o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/1/2 |
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| author | Ruizhi Hu Xizi Yang Jianhua He Shusong Wu |
| author_facet | Ruizhi Hu Xizi Yang Jianhua He Shusong Wu |
| author_sort | Ruizhi Hu |
| collection | DOAJ |
| description | This review systematically examines the influence of oxidative stress on the reproductive function of male livestock, with a particular focus on the modulation of autophagy. Spermatogenesis, a highly precise biological process, is vulnerable to a range of internal and external factors, among which oxidative stress notably disrupts autophagic processes within the testes. This disruption results in diminished sperm quality, impaired testosterone synthesis, and compromised integrity of the blood–testis barrier. Furthermore, this review elucidates the molecular mechanisms by which oxidative stress-induced autophagy dysfunction impairs spermatogenesis and mitochondrial function, consequently reducing sperm motility. These findings aim to provide a theoretical foundation and serve as a reference for improving reproductive performance and sperm quality in livestock. |
| format | Article |
| id | doaj-art-85a9f41a65514dfbae0287cf16913b1a |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-85a9f41a65514dfbae0287cf16913b1a2025-01-24T13:19:03ZengMDPI AGAntioxidants2076-39212024-12-01141210.3390/antiox14010002Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ FertilityRuizhi Hu0Xizi Yang1Jianhua He2Shusong Wu3National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaThis review systematically examines the influence of oxidative stress on the reproductive function of male livestock, with a particular focus on the modulation of autophagy. Spermatogenesis, a highly precise biological process, is vulnerable to a range of internal and external factors, among which oxidative stress notably disrupts autophagic processes within the testes. This disruption results in diminished sperm quality, impaired testosterone synthesis, and compromised integrity of the blood–testis barrier. Furthermore, this review elucidates the molecular mechanisms by which oxidative stress-induced autophagy dysfunction impairs spermatogenesis and mitochondrial function, consequently reducing sperm motility. These findings aim to provide a theoretical foundation and serve as a reference for improving reproductive performance and sperm quality in livestock.https://www.mdpi.com/2076-3921/14/1/2oxidative stressautophagyspermatogenesissperm quality |
| spellingShingle | Ruizhi Hu Xizi Yang Jianhua He Shusong Wu Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility Antioxidants oxidative stress autophagy spermatogenesis sperm quality |
| title | Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility |
| title_full | Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility |
| title_fullStr | Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility |
| title_full_unstemmed | Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility |
| title_short | Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility |
| title_sort | oxidative stress and autophagy unraveling the hidden threat to boars fertility |
| topic | oxidative stress autophagy spermatogenesis sperm quality |
| url | https://www.mdpi.com/2076-3921/14/1/2 |
| work_keys_str_mv | AT ruizhihu oxidativestressandautophagyunravelingthehiddenthreattoboarsfertility AT xiziyang oxidativestressandautophagyunravelingthehiddenthreattoboarsfertility AT jianhuahe oxidativestressandautophagyunravelingthehiddenthreattoboarsfertility AT shusongwu oxidativestressandautophagyunravelingthehiddenthreattoboarsfertility |