Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells
The carboxylated short multiwalled carbon nanotubes (Sh-MWCNT-COOH) were first modified by isatin derivative to form Sh-MWCNT-Amide and then by hydrazine to produce Sh-MWCNT-Spiro. All products were characterized by the Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron m...
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/697839 |
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| author | Hasan Tahermansouri Farshid Chitgar |
| author_facet | Hasan Tahermansouri Farshid Chitgar |
| author_sort | Hasan Tahermansouri |
| collection | DOAJ |
| description | The carboxylated short multiwalled carbon nanotubes (Sh-MWCNT-COOH) were first modified by isatin derivative to form Sh-MWCNT-Amide and then by hydrazine to produce Sh-MWCNT-Spiro. All products were characterized by the Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscope, elemental analysis, thermogravimetric analysis, derivative thermogravimetric, solubility test, and cellular investigations. This functionalization has been chosen due to active sites of OH and carbonyl groups in Sh-MWCNT-Amide which might be used as functional materials in the future. Toxicity of these samples was evaluated with human gastric and colon cancer cells, and killed cell numbers were measured by reduction of living cells with 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide. Cellular results showed high toxicity of Sh-MWCNT-Amide in all samples investigated. |
| format | Article |
| id | doaj-art-85a7858415bd4600beea24eee72f2f44 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-85a7858415bd4600beea24eee72f2f442025-02-03T06:06:00ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/697839697839Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer CellsHasan Tahermansouri0Farshid Chitgar1Department of Chemistry, Ayatollah Amoli branch, Islamic Azad University, P.O. Box 678, Amol, IranDepartment of Chemistry, Ayatollah Amoli branch, Islamic Azad University, P.O. Box 678, Amol, IranThe carboxylated short multiwalled carbon nanotubes (Sh-MWCNT-COOH) were first modified by isatin derivative to form Sh-MWCNT-Amide and then by hydrazine to produce Sh-MWCNT-Spiro. All products were characterized by the Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscope, elemental analysis, thermogravimetric analysis, derivative thermogravimetric, solubility test, and cellular investigations. This functionalization has been chosen due to active sites of OH and carbonyl groups in Sh-MWCNT-Amide which might be used as functional materials in the future. Toxicity of these samples was evaluated with human gastric and colon cancer cells, and killed cell numbers were measured by reduction of living cells with 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide. Cellular results showed high toxicity of Sh-MWCNT-Amide in all samples investigated.http://dx.doi.org/10.1155/2013/697839 |
| spellingShingle | Hasan Tahermansouri Farshid Chitgar Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells Journal of Chemistry |
| title | Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells |
| title_full | Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells |
| title_fullStr | Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells |
| title_full_unstemmed | Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells |
| title_short | Synthesis of Isatin Derivative on the Short Multiwalled Carbon Nanotubes and Their Effect on the MKN-45 and SW742 Cancer Cells |
| title_sort | synthesis of isatin derivative on the short multiwalled carbon nanotubes and their effect on the mkn 45 and sw742 cancer cells |
| url | http://dx.doi.org/10.1155/2013/697839 |
| work_keys_str_mv | AT hasantahermansouri synthesisofisatinderivativeontheshortmultiwalledcarbonnanotubesandtheireffectonthemkn45andsw742cancercells AT farshidchitgar synthesisofisatinderivativeontheshortmultiwalledcarbonnanotubesandtheireffectonthemkn45andsw742cancercells |