ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis
Abstract Membrane contact sites are specialized regions where organelle membranes are in close proximity, enabling lipid transfer while preserving membrane identity. In plants, ER‒chloroplast contact sites are critical for maintaining glycerolipid homeostasis. This review examines the lipid-modifyin...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-025-02239-2 |
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| author | Carolina Huercano Miriam Moya-Barrientos Oliver Cuevas Victoria Sanchez-Vera Noemi Ruiz-Lopez |
| author_facet | Carolina Huercano Miriam Moya-Barrientos Oliver Cuevas Victoria Sanchez-Vera Noemi Ruiz-Lopez |
| author_sort | Carolina Huercano |
| collection | DOAJ |
| description | Abstract Membrane contact sites are specialized regions where organelle membranes are in close proximity, enabling lipid transfer while preserving membrane identity. In plants, ER‒chloroplast contact sites are critical for maintaining glycerolipid homeostasis. This review examines the lipid-modifying and lipid-transfer proteins/complexes involved in these processes. Key proteins at these sites, including components of the TGD and VAP27‒ORP2A complexes, as well as Sec14 proteins, facilitate lipid exchange. Additionally, the roles of lipid-modifying proteins at these contact sites are discussed. Despite significant progress, further research is needed to identify additional proteins, investigate ER‒chloroplast dynamics under stress and explore ER contact sites in non-chloroplast plastids. |
| format | Article |
| id | doaj-art-85a2a36b6cb74b0cabb843d3d4fe8b91 |
| institution | OA Journals |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-85a2a36b6cb74b0cabb843d3d4fe8b912025-08-20T02:29:51ZengBMCBMC Biology1741-70072025-05-0123111910.1186/s12915-025-02239-2ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesisCarolina Huercano0Miriam Moya-Barrientos1Oliver Cuevas2Victoria Sanchez-Vera3Noemi Ruiz-Lopez4Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora”, Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de TeatinosInstituto de Hortofruticultura Subtropical y Mediterránea “La Mayora”, Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de TeatinosInstituto de Hortofruticultura Subtropical y Mediterránea “La Mayora”, Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de TeatinosInstituto de Hortofruticultura Subtropical y Mediterránea “La Mayora”, Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de TeatinosInstituto de Hortofruticultura Subtropical y Mediterránea “La Mayora”, Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de TeatinosAbstract Membrane contact sites are specialized regions where organelle membranes are in close proximity, enabling lipid transfer while preserving membrane identity. In plants, ER‒chloroplast contact sites are critical for maintaining glycerolipid homeostasis. This review examines the lipid-modifying and lipid-transfer proteins/complexes involved in these processes. Key proteins at these sites, including components of the TGD and VAP27‒ORP2A complexes, as well as Sec14 proteins, facilitate lipid exchange. Additionally, the roles of lipid-modifying proteins at these contact sites are discussed. Despite significant progress, further research is needed to identify additional proteins, investigate ER‒chloroplast dynamics under stress and explore ER contact sites in non-chloroplast plastids.https://doi.org/10.1186/s12915-025-02239-2Contact sitesPlastidChloroplastEndoplasmic reticulumGlycerolipidLipid transfer |
| spellingShingle | Carolina Huercano Miriam Moya-Barrientos Oliver Cuevas Victoria Sanchez-Vera Noemi Ruiz-Lopez ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis BMC Biology Contact sites Plastid Chloroplast Endoplasmic reticulum Glycerolipid Lipid transfer |
| title | ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis |
| title_full | ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis |
| title_fullStr | ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis |
| title_full_unstemmed | ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis |
| title_short | ER–plastid contact sites as molecular crossroads for plastid lipid biosynthesis |
| title_sort | er plastid contact sites as molecular crossroads for plastid lipid biosynthesis |
| topic | Contact sites Plastid Chloroplast Endoplasmic reticulum Glycerolipid Lipid transfer |
| url | https://doi.org/10.1186/s12915-025-02239-2 |
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