Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature
Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. We present an extremely rare case in which AC occurred in a 2-year-old girl, who had a tumor in the right mandible. Radiographic findings showed a multi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2020/4072890 |
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| author | Ngoc Bao Vu Ngoc Tuyen Le Risa Chaisuparat Pasutha Thunyakitpisal Ngoc Minh Tran |
| author_facet | Ngoc Bao Vu Ngoc Tuyen Le Risa Chaisuparat Pasutha Thunyakitpisal Ngoc Minh Tran |
| author_sort | Ngoc Bao Vu |
| collection | DOAJ |
| description | Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. We present an extremely rare case in which AC occurred in a 2-year-old girl, who had a tumor in the right mandible. Radiographic findings showed a multilocular, poorly defined, and mixed radiolucent-radiopaque lesion in the region of teeth #84 to #85, with bone and tooth root resorption. Computed tomography revealed buccal cortex destruction, tumor infiltration of soft tissue, and enlarged nodes. Incisional biopsy showed histomorphological features of AC. Immunohistochemical analysis exhibited a positive result for Cytokeratin (CK) 19 and overexpression of p53 and Ki67. The patient underwent right hemimandibulectomy and neck dissection. The final pathology was consistent with the initial diagnosis of AC. The patient did not exhibit signs of recurrence or metastasis within 2 years postoperatively. Given the rarity of this disease and the age of the patient, this report constitutes a valuable contribution to the current literature. |
| format | Article |
| id | doaj-art-85a0fa7c4b4c47d2b6bd1c7390a54500 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-85a0fa7c4b4c47d2b6bd1c7390a545002025-02-03T05:51:45ZengWileyCase Reports in Dentistry2090-64472090-64552020-01-01202010.1155/2020/40728904072890Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the LiteratureNgoc Bao Vu0Ngoc Tuyen Le1Risa Chaisuparat2Pasutha Thunyakitpisal3Ngoc Minh Tran4Dental Biomaterials Science Program, Graduate School, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Maxillofacial Reconstructive Surgery, Hanoi National Hospital of Odonto-Stomatology, Hanoi 100000, VietnamDepartment of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, ThailandResearch Unit of Herbal Medicine, Biomaterial, And Material for Dental Treatment, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Pathology, Hanoi Medical University, Hanoi 100000, VietnamAmeloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. We present an extremely rare case in which AC occurred in a 2-year-old girl, who had a tumor in the right mandible. Radiographic findings showed a multilocular, poorly defined, and mixed radiolucent-radiopaque lesion in the region of teeth #84 to #85, with bone and tooth root resorption. Computed tomography revealed buccal cortex destruction, tumor infiltration of soft tissue, and enlarged nodes. Incisional biopsy showed histomorphological features of AC. Immunohistochemical analysis exhibited a positive result for Cytokeratin (CK) 19 and overexpression of p53 and Ki67. The patient underwent right hemimandibulectomy and neck dissection. The final pathology was consistent with the initial diagnosis of AC. The patient did not exhibit signs of recurrence or metastasis within 2 years postoperatively. Given the rarity of this disease and the age of the patient, this report constitutes a valuable contribution to the current literature.http://dx.doi.org/10.1155/2020/4072890 |
| spellingShingle | Ngoc Bao Vu Ngoc Tuyen Le Risa Chaisuparat Pasutha Thunyakitpisal Ngoc Minh Tran Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature Case Reports in Dentistry |
| title | Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature |
| title_full | Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature |
| title_fullStr | Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature |
| title_full_unstemmed | Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature |
| title_short | Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature |
| title_sort | ameloblastic carcinoma in a 2 year old child a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2020/4072890 |
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