Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature
Hepatocellular carcinoma is the fifth most common malignancy and the third leading mortality cause worldwide. It typically develops secondarily to liver cirrhosis, due to hepatitis B or C infection, alcohol abuse, metabolic disease, and so forth. According to the American Association for the Study o...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/878763 |
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| author | Monika Pazgan-Simon Sylwia Serafinska Justyna Janocha-Litwin Krzysztof Simon Jolanta Zuwala-Jagiello |
| author_facet | Monika Pazgan-Simon Sylwia Serafinska Justyna Janocha-Litwin Krzysztof Simon Jolanta Zuwala-Jagiello |
| author_sort | Monika Pazgan-Simon |
| collection | DOAJ |
| description | Hepatocellular carcinoma is the fifth most common malignancy and the third leading mortality cause worldwide. It typically develops secondarily to liver cirrhosis, due to hepatitis B or C infection, alcohol abuse, metabolic disease, and so forth. According to the American Association for the Study of Liver Diseases (AASLD) guidelines, which constitute diagnostic standards, the diagnosis of primary hepatocellular carcinoma (HCC) should be based on contrast-enhanced imaging. Lesion hyperenhancement should be observed throughout the arterial phase, followed by the washout during the venous phase. The diagnosis can also be based on the histopathological evaluation of liver biopsy specimen. Although the standards are clear, we often see patients with advanced HCC in clinical practice, who cannot be offered any effective treatment. Patients with chronic liver disease, presenting with inconclusive and changeable test results, constitute a separate problem. In such cases the diagnostic process is typically long-term and delayed. In this paper we present three case reports where the diagnosis could not be made promptly and the patients died as a result of a delayed diagnostic process. |
| format | Article |
| id | doaj-art-859565d02006437586ed1e751980eaab |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-859565d02006437586ed1e751980eaab2025-02-03T05:59:17ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/878763878763Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the LiteratureMonika Pazgan-Simon0Sylwia Serafinska1Justyna Janocha-Litwin2Krzysztof Simon3Jolanta Zuwala-Jagiello4Infectious Disease Department, Wroclaw Medical University, Wroclaw, PolandInfectious Disease Department, Division of Infectious Disease and Hepatology, Wroclaw Medical University, Wroclaw, PolandInfectious Disease Department, Wroclaw Medical University, Wroclaw, PolandInfectious Disease Department, Division of Infectious Disease and Hepatology, Wroclaw Medical University, Wroclaw, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, Wroclaw, PolandHepatocellular carcinoma is the fifth most common malignancy and the third leading mortality cause worldwide. It typically develops secondarily to liver cirrhosis, due to hepatitis B or C infection, alcohol abuse, metabolic disease, and so forth. According to the American Association for the Study of Liver Diseases (AASLD) guidelines, which constitute diagnostic standards, the diagnosis of primary hepatocellular carcinoma (HCC) should be based on contrast-enhanced imaging. Lesion hyperenhancement should be observed throughout the arterial phase, followed by the washout during the venous phase. The diagnosis can also be based on the histopathological evaluation of liver biopsy specimen. Although the standards are clear, we often see patients with advanced HCC in clinical practice, who cannot be offered any effective treatment. Patients with chronic liver disease, presenting with inconclusive and changeable test results, constitute a separate problem. In such cases the diagnostic process is typically long-term and delayed. In this paper we present three case reports where the diagnosis could not be made promptly and the patients died as a result of a delayed diagnostic process.http://dx.doi.org/10.1155/2015/878763 |
| spellingShingle | Monika Pazgan-Simon Sylwia Serafinska Justyna Janocha-Litwin Krzysztof Simon Jolanta Zuwala-Jagiello Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature Case Reports in Oncological Medicine |
| title | Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature |
| title_full | Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature |
| title_fullStr | Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature |
| title_full_unstemmed | Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature |
| title_short | Diagnostic Challenges in Primary Hepatocellular Carcinoma: Case Reports and Review of the Literature |
| title_sort | diagnostic challenges in primary hepatocellular carcinoma case reports and review of the literature |
| url | http://dx.doi.org/10.1155/2015/878763 |
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