Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China
Abstract Background This study aimed to describe the epidemiological trends of Mycoplasma pneumoniae (MP) infection among children with acute respiratory tract infections (ARTIs) before, during and after the COVID-19 pandemic, and evaluating the impact of non-pharmaceutical interventions (NPIs) on t...
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2025-01-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-01846-7 |
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| author | Yuzhu Miao Jungen Li Linlin Huang Ting Shi Tingbo Jiang |
| author_facet | Yuzhu Miao Jungen Li Linlin Huang Ting Shi Tingbo Jiang |
| author_sort | Yuzhu Miao |
| collection | DOAJ |
| description | Abstract Background This study aimed to describe the epidemiological trends of Mycoplasma pneumoniae (MP) infection among children with acute respiratory tract infections (ARTIs) before, during and after the COVID-19 pandemic, and evaluating the impact of non-pharmaceutical interventions (NPIs) on the epidemiology of MP infection. Methods Children with ARTIs admitted to the Children’s Hospital of Soochow University (SCH) from January 2010 to December 2023 and underwent MP nucleic acid PCR assay were included. Clinical data on age, sex, onset time and detection result were collected and analyzed. Results All of the 122,984 inpatients were enrolled, in which 20.8% (25659/122984) of the children with MP tested positive, including 19.4% (14139/72662) for male and 22.9% (11520/50322) for female. It was a statistically significant difference between the two genders (p < 0.05). In addition, the positive rate of MP was the highest in the age group > 6 years old each year (p < 0.05). During 14-year period, the detection rate of MP has experienced four peaks in 2012, 2013, 2019, and 2023. Before the NPIs the prevalence of MP showed seasonality, and the number and rate of MP positivity reached their peak in August. However, the rate of MP positivity remained at a low level during the NPIs. After the abolition of NPIs, the MP positivity rate obviously increased and remained at a high level. Conclusions The NPIs could reduce the spread of MP infection and change its epidemic season, but it has not changed the susceptible population of MP infection. |
| format | Article |
| id | doaj-art-858fc4b21d784f92b242ccfb35ecc979 |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Italian Journal of Pediatrics |
| spelling | doaj-art-858fc4b21d784f92b242ccfb35ecc9792025-01-26T12:45:09ZengBMCItalian Journal of Pediatrics1824-72882025-01-015111710.1186/s13052-025-01846-7Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in ChinaYuzhu Miao0Jungen Li1Linlin Huang2Ting Shi3Tingbo Jiang4Department of Cardiovascular Medicine, The First Affiliated Hospital of Soochow UniversityDepartment of Emergency Medicine, The First Affiliated Hospital of Soochow UniversityPediatric Intensive Care Unit, Children’s Hospital of Soochow UniversityDepartment of Infectious Diseases, Children’s Hospital of Soochow UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Soochow UniversityAbstract Background This study aimed to describe the epidemiological trends of Mycoplasma pneumoniae (MP) infection among children with acute respiratory tract infections (ARTIs) before, during and after the COVID-19 pandemic, and evaluating the impact of non-pharmaceutical interventions (NPIs) on the epidemiology of MP infection. Methods Children with ARTIs admitted to the Children’s Hospital of Soochow University (SCH) from January 2010 to December 2023 and underwent MP nucleic acid PCR assay were included. Clinical data on age, sex, onset time and detection result were collected and analyzed. Results All of the 122,984 inpatients were enrolled, in which 20.8% (25659/122984) of the children with MP tested positive, including 19.4% (14139/72662) for male and 22.9% (11520/50322) for female. It was a statistically significant difference between the two genders (p < 0.05). In addition, the positive rate of MP was the highest in the age group > 6 years old each year (p < 0.05). During 14-year period, the detection rate of MP has experienced four peaks in 2012, 2013, 2019, and 2023. Before the NPIs the prevalence of MP showed seasonality, and the number and rate of MP positivity reached their peak in August. However, the rate of MP positivity remained at a low level during the NPIs. After the abolition of NPIs, the MP positivity rate obviously increased and remained at a high level. Conclusions The NPIs could reduce the spread of MP infection and change its epidemic season, but it has not changed the susceptible population of MP infection.https://doi.org/10.1186/s13052-025-01846-7Mycoplasma pneumoniaeChildrenEpidemiologyNPIs |
| spellingShingle | Yuzhu Miao Jungen Li Linlin Huang Ting Shi Tingbo Jiang Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China Italian Journal of Pediatrics Mycoplasma pneumoniae Children Epidemiology NPIs |
| title | Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China |
| title_full | Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China |
| title_fullStr | Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China |
| title_full_unstemmed | Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China |
| title_short | Mycoplasma pneumoniae detections in children with acute respiratory infection, 2010–2023: a large sample study in China |
| title_sort | mycoplasma pneumoniae detections in children with acute respiratory infection 2010 2023 a large sample study in china |
| topic | Mycoplasma pneumoniae Children Epidemiology NPIs |
| url | https://doi.org/10.1186/s13052-025-01846-7 |
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