Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives
1,3,5-Triazines and pyrimidine-2,4,6-triones belong to that class of compounds which are well known in literature for possessing wide range of biological activities. Here, we report a new family of compounds that encompasses these two structures. The union of both heterocycles was carried out throug...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/5702962 |
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| author | Anamika Sharma Yahya Jad Mohammed R. H. Siddiqui Beatriz G. de la Torre Fernando Albericio Ayman El-Faham |
| author_facet | Anamika Sharma Yahya Jad Mohammed R. H. Siddiqui Beatriz G. de la Torre Fernando Albericio Ayman El-Faham |
| author_sort | Anamika Sharma |
| collection | DOAJ |
| description | 1,3,5-Triazines and pyrimidine-2,4,6-triones belong to that class of compounds which are well known in literature for possessing wide range of biological activities. Here, we report a new family of compounds that encompasses these two structures. The union of both heterocycles was carried out through a hydrazone moiety incorporated into an acetyl group at the position 5 of 1,3-dimethyl pyrimidine derivative. The synthetic strategy adopted allowed the preparation of the target compounds with excellent yields and good purities. The synthesized compounds were well characterized by NMR (1H and 13C), HRMS, and elemental analysis. Furthermore, the tautomerism of enhydrazine versus hydrazone has also been studied. |
| format | Article |
| id | doaj-art-8585e69acc064c2ca8389edc7211db7c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-8585e69acc064c2ca8389edc7211db7c2025-02-03T06:05:21ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/57029625702962Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone DerivativesAnamika Sharma0Yahya Jad1Mohammed R. H. Siddiqui2Beatriz G. de la Torre3Fernando Albericio4Ayman El-Faham5School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South AfricaSchool of Health Sciences, University of KwaZulu-Natal, Durban 4001, South AfricaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaSchool of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4001, South AfricaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia1,3,5-Triazines and pyrimidine-2,4,6-triones belong to that class of compounds which are well known in literature for possessing wide range of biological activities. Here, we report a new family of compounds that encompasses these two structures. The union of both heterocycles was carried out through a hydrazone moiety incorporated into an acetyl group at the position 5 of 1,3-dimethyl pyrimidine derivative. The synthetic strategy adopted allowed the preparation of the target compounds with excellent yields and good purities. The synthesized compounds were well characterized by NMR (1H and 13C), HRMS, and elemental analysis. Furthermore, the tautomerism of enhydrazine versus hydrazone has also been studied.http://dx.doi.org/10.1155/2017/5702962 |
| spellingShingle | Anamika Sharma Yahya Jad Mohammed R. H. Siddiqui Beatriz G. de la Torre Fernando Albericio Ayman El-Faham Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives Journal of Chemistry |
| title | Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives |
| title_full | Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives |
| title_fullStr | Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives |
| title_full_unstemmed | Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives |
| title_short | Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives |
| title_sort | synthesis characterization and tautomerism of 1 3 dimethyl pyrimidine 2 4 6 trione s triazinyl hydrazine hydrazone derivatives |
| url | http://dx.doi.org/10.1155/2017/5702962 |
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