MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate
A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB) made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains ap...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2012/216137 |
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| author | Erich K. Odermatt Lutz Funk Rainer Bargon David P. Martin Said Rizk Simon F. Williams |
| author_facet | Erich K. Odermatt Lutz Funk Rainer Bargon David P. Martin Said Rizk Simon F. Williams |
| author_sort | Erich K. Odermatt |
| collection | DOAJ |
| description | A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB) made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strength in vivo and is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ) has no residual strength in vivo after 12 weeks. In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication. |
| format | Article |
| id | doaj-art-8582d072bdd7490cb163f96eb498f525 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-8582d072bdd7490cb163f96eb498f5252025-02-03T07:24:12ZengWileyInternational Journal of Polymer Science1687-94221687-94302012-01-01201210.1155/2012/216137216137MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-HydroxybutyrateErich K. Odermatt0Lutz Funk1Rainer Bargon2David P. Martin3Said Rizk4Simon F. Williams5Aesculap AG, Am Aesculap-Platz, 78532 Tuttlingen, GermanyB. Braun Surgical S.A., Carretera de Terrassa 121, 08191 Rubi, SpainAesculap AG, Am Aesculap-Platz, 78532 Tuttlingen, GermanyTepha Inc., 99 Hayden Avenue, Lexington, MA 02421, USATepha Inc., 99 Hayden Avenue, Lexington, MA 02421, USATepha Inc., 99 Hayden Avenue, Lexington, MA 02421, USAA long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB) made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strength in vivo and is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ) has no residual strength in vivo after 12 weeks. In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication.http://dx.doi.org/10.1155/2012/216137 |
| spellingShingle | Erich K. Odermatt Lutz Funk Rainer Bargon David P. Martin Said Rizk Simon F. Williams MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate International Journal of Polymer Science |
| title | MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate |
| title_full | MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate |
| title_fullStr | MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate |
| title_full_unstemmed | MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate |
| title_short | MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate |
| title_sort | monomax suture a new long term absorbable monofilament suture made from poly 4 hydroxybutyrate |
| url | http://dx.doi.org/10.1155/2012/216137 |
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