Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation
Vascularized composite allotransplantation (VCA) is an effective treatment option for patients suffering from limb loss or severe disfigurement. However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/757310 |
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| author | Theresa Hautz Dolores Wolfram Johanna Grahammer Ravi Starzl Christoph Krapf Johann Pratschke W. P. Andrew Lee Gerald Brandacher Stefan Schneeberger |
| author_facet | Theresa Hautz Dolores Wolfram Johanna Grahammer Ravi Starzl Christoph Krapf Johann Pratschke W. P. Andrew Lee Gerald Brandacher Stefan Schneeberger |
| author_sort | Theresa Hautz |
| collection | DOAJ |
| description | Vascularized composite allotransplantation (VCA) is an effective treatment option for patients suffering from limb loss or severe disfigurement. However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft survival. To widen the scope of this quality-of-life improving procedure minimization of immunosuppression in order to limit risks and side effects is needed. In some aspects, the molecular mechanisms and dynamics of skin allograft rejection seem similar to inflammatory skin conditions. T cells are key players in skin rejection and are recruited to the skin via activation of adhesion molecules, cytokines, and chemokines. Blocking these molecules has not only shown success in the treatment of inflammatory dermatoses, but also prolonged graft survival in various models of solid organ transplantation. In addition to T cell recruitment, ectopic lymphoid structures within the allograft associated with chronic rejection in solid organ transplantation might contribute to the strong alloimmune response towards the skin. Selectively targeting the molecules involved offers exciting novel therapeutic options in the prevention and treatment of skin rejection after VCA. |
| format | Article |
| id | doaj-art-857d233b02f8435db20316b64152eaef |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-857d233b02f8435db20316b64152eaef2025-02-03T01:07:33ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/757310757310Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite AllotransplantationTheresa Hautz0Dolores Wolfram1Johanna Grahammer2Ravi Starzl3Christoph Krapf4Johann Pratschke5W. P. Andrew Lee6Gerald Brandacher7Stefan Schneeberger8Center for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, AustriaDepartment of Plastic and Reconstructive Surgery, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, AustriaCenter for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, AustriaLanguage Technologies Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USADepartment of Cardiac Surgery, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, AustriaCenter for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, AustriaDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USACenter for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, AustriaVascularized composite allotransplantation (VCA) is an effective treatment option for patients suffering from limb loss or severe disfigurement. However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft survival. To widen the scope of this quality-of-life improving procedure minimization of immunosuppression in order to limit risks and side effects is needed. In some aspects, the molecular mechanisms and dynamics of skin allograft rejection seem similar to inflammatory skin conditions. T cells are key players in skin rejection and are recruited to the skin via activation of adhesion molecules, cytokines, and chemokines. Blocking these molecules has not only shown success in the treatment of inflammatory dermatoses, but also prolonged graft survival in various models of solid organ transplantation. In addition to T cell recruitment, ectopic lymphoid structures within the allograft associated with chronic rejection in solid organ transplantation might contribute to the strong alloimmune response towards the skin. Selectively targeting the molecules involved offers exciting novel therapeutic options in the prevention and treatment of skin rejection after VCA.http://dx.doi.org/10.1155/2012/757310 |
| spellingShingle | Theresa Hautz Dolores Wolfram Johanna Grahammer Ravi Starzl Christoph Krapf Johann Pratschke W. P. Andrew Lee Gerald Brandacher Stefan Schneeberger Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation Clinical and Developmental Immunology |
| title | Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation |
| title_full | Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation |
| title_fullStr | Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation |
| title_full_unstemmed | Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation |
| title_short | Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation |
| title_sort | mechanisms and mediators of inflammation potential models for skin rejection and targeted therapy in vascularized composite allotransplantation |
| url | http://dx.doi.org/10.1155/2012/757310 |
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