Photostability and Photostabilization of Drugs and Drug Products
Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2016/8135608 |
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| _version_ | 1832548471453777920 |
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| author | Iqbal Ahmad Sofia Ahmed Zubair Anwar Muhammad Ali Sheraz Marek Sikorski |
| author_facet | Iqbal Ahmad Sofia Ahmed Zubair Anwar Muhammad Ali Sheraz Marek Sikorski |
| author_sort | Iqbal Ahmad |
| collection | DOAJ |
| description | Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the concept of photostability and related aspects and the literature available in the field. It highlights the role of the photochemistry in the photostability studies, describes the functional groups important for the photoreactivity of drugs, explains photophysical processes, and deals with the kinetics of photochemical reactions. The various modes of photodegradation of drugs with examples of selected compounds are presented. The biological consequences of the effect of light on the drug degradation are described. The photostability testing of drugs and drug products and the requirements under ICH guideline are discussed. Some information on the packaging requirements for the formulated products is provided. The various methods used for the photostabilization of solid and liquid dosage forms are also discussed. |
| format | Article |
| id | doaj-art-857c2e1228a245ee85cdede026d41b30 |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-857c2e1228a245ee85cdede026d41b302025-02-03T06:13:56ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2016-01-01201610.1155/2016/81356088135608Photostability and Photostabilization of Drugs and Drug ProductsIqbal Ahmad0Sofia Ahmed1Zubair Anwar2Muhammad Ali Sheraz3Marek Sikorski4Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, PakistanBaqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, PakistanBaqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, PakistanBaqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, PakistanFaculty of Chemistry, Adam Mickiewicz University in Poznan, Umultowska 89b, 61–64 Poznan, PolandPhotostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the concept of photostability and related aspects and the literature available in the field. It highlights the role of the photochemistry in the photostability studies, describes the functional groups important for the photoreactivity of drugs, explains photophysical processes, and deals with the kinetics of photochemical reactions. The various modes of photodegradation of drugs with examples of selected compounds are presented. The biological consequences of the effect of light on the drug degradation are described. The photostability testing of drugs and drug products and the requirements under ICH guideline are discussed. Some information on the packaging requirements for the formulated products is provided. The various methods used for the photostabilization of solid and liquid dosage forms are also discussed.http://dx.doi.org/10.1155/2016/8135608 |
| spellingShingle | Iqbal Ahmad Sofia Ahmed Zubair Anwar Muhammad Ali Sheraz Marek Sikorski Photostability and Photostabilization of Drugs and Drug Products International Journal of Photoenergy |
| title | Photostability and Photostabilization of Drugs and Drug Products |
| title_full | Photostability and Photostabilization of Drugs and Drug Products |
| title_fullStr | Photostability and Photostabilization of Drugs and Drug Products |
| title_full_unstemmed | Photostability and Photostabilization of Drugs and Drug Products |
| title_short | Photostability and Photostabilization of Drugs and Drug Products |
| title_sort | photostability and photostabilization of drugs and drug products |
| url | http://dx.doi.org/10.1155/2016/8135608 |
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