ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice

ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice

Abstract Background Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and diminished life expectancy. Despite significant advancements in therape...

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Bibliographic Details
Main Authors: Ninon Foussard, Célia Bourguignon, Virginie Grouthier, Caroline Caradu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cardiovascular Diabetology
Subjects:
Limb ischemia
Perfusion
Microcirculation
Endothelial activation
Online Access:https://doi.org/10.1186/s12933-025-02573-3
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