TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner

TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner

Objectives: Dysregulation of lipid homeostasis pathway causes many liver diseases, including hepatic steatosis. One of the primary factors contributing to lipid accumulation is fatty acid uptake by the liver. Transmembrane protein 135 (TMEM135), which exists in mitochondria and peroxisomes, particip...

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Main Authors: Arun Chhetri, Channy Park, Hyunsoo Kim, Laxman Manandhar, Chagtsalmaa Chuluunbaatar, Jaetaek Hwang, Xiaofan Wei, Gyuho Jang, Batching Chinbold, Hyug Moo Kwon, Sang-wook Lee, Raekil Park
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Molecular Metabolism
Subjects:
TMEM135
Lipid accumulation
CD36
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002114
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