Immune Cells and Inflammation in Diabetic Nephropathy
Diabetic nephropathy (DN) is a serious complication of diabetes. At its core, DN is a metabolic disorder which can also manifest itself in terms of local inflammation in the kidneys. Such inflammation can then drive the classical markers of fibrosis and structural remodeling. As a result, resolution...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1841690 |
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| _version_ | 1832556900852432896 |
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| author | Zihan Zheng Feng Zheng |
| author_facet | Zihan Zheng Feng Zheng |
| author_sort | Zihan Zheng |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is a serious complication of diabetes. At its core, DN is a metabolic disorder which can also manifest itself in terms of local inflammation in the kidneys. Such inflammation can then drive the classical markers of fibrosis and structural remodeling. As a result, resolution of immune-mediated inflammation is critical towards achieving a cure for DN. Many immune cells play a part in DN, including key members of both the innate and adaptive immune systems. While these cells were classically understood to primarily function against pathogen insult, it has also become increasingly clear that they also serve a major role as internal sensors of damage. In fact, damage sensing may serve as the impetus for much of the inflammation that occurs in DN, in a vicious positive feedback cycle. Although direct targeting of these proinflammatory cells may be difficult, new approaches that focus on their metabolic profiles may be able to alleviate DN significantly, especially since dysregulation of the local metabolic environment may well be responsible for triggering inflammation to begin with. In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles. |
| format | Article |
| id | doaj-art-8557453880114362b4b2e19b18ce887d |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8557453880114362b4b2e19b18ce887d2025-02-03T05:44:07ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/18416901841690Immune Cells and Inflammation in Diabetic NephropathyZihan Zheng0Feng Zheng1College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USADepartment of Nephrology, Advanced Institute for Medical Sciences, Second Hospital, Dalian Medical University, Dalian 116023, ChinaDiabetic nephropathy (DN) is a serious complication of diabetes. At its core, DN is a metabolic disorder which can also manifest itself in terms of local inflammation in the kidneys. Such inflammation can then drive the classical markers of fibrosis and structural remodeling. As a result, resolution of immune-mediated inflammation is critical towards achieving a cure for DN. Many immune cells play a part in DN, including key members of both the innate and adaptive immune systems. While these cells were classically understood to primarily function against pathogen insult, it has also become increasingly clear that they also serve a major role as internal sensors of damage. In fact, damage sensing may serve as the impetus for much of the inflammation that occurs in DN, in a vicious positive feedback cycle. Although direct targeting of these proinflammatory cells may be difficult, new approaches that focus on their metabolic profiles may be able to alleviate DN significantly, especially since dysregulation of the local metabolic environment may well be responsible for triggering inflammation to begin with. In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles.http://dx.doi.org/10.1155/2016/1841690 |
| spellingShingle | Zihan Zheng Feng Zheng Immune Cells and Inflammation in Diabetic Nephropathy Journal of Diabetes Research |
| title | Immune Cells and Inflammation in Diabetic Nephropathy |
| title_full | Immune Cells and Inflammation in Diabetic Nephropathy |
| title_fullStr | Immune Cells and Inflammation in Diabetic Nephropathy |
| title_full_unstemmed | Immune Cells and Inflammation in Diabetic Nephropathy |
| title_short | Immune Cells and Inflammation in Diabetic Nephropathy |
| title_sort | immune cells and inflammation in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2016/1841690 |
| work_keys_str_mv | AT zihanzheng immunecellsandinflammationindiabeticnephropathy AT fengzheng immunecellsandinflammationindiabeticnephropathy |