Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase
It is well known that the thrombin obtained from animal is available in clinical treatment, which plays an important role in hemostasis and the treatment of hemorrhagic diseases. However, how to achieve complete hemostasis in 2 min is still a challenge. In this report, the thrombin hemostatic has be...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2015/985286 |
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| author | Tengfei Yu Yuepeng Guan Xia Xie Yaqin Huang Jie Tang |
| author_facet | Tengfei Yu Yuepeng Guan Xia Xie Yaqin Huang Jie Tang |
| author_sort | Tengfei Yu |
| collection | DOAJ |
| description | It is well known that the thrombin obtained from animal is available in clinical treatment, which plays an important role in hemostasis and the treatment of hemorrhagic diseases. However, how to achieve complete hemostasis in 2 min is still a challenge. In this report, the thrombin hemostatic has been improved using the cross-linked gelatin by microbial transglutaminase, and its efficacy was demonstrated by the vitro experiment. Compared with the traditional thrombin hemostatic the clotting time with the improved hemostat is significantly shorter. It may rapidly stop blood loss, which would provide a simple, safe, and cost-effective surgical sealant. |
| format | Article |
| id | doaj-art-8545a3832d0148f383049fe0cb1d0053 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-8545a3832d0148f383049fe0cb1d00532025-02-03T01:09:32ZengWileyInternational Journal of Polymer Science1687-94221687-94302015-01-01201510.1155/2015/985286985286Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial TransglutaminaseTengfei Yu0Yuepeng Guan1Xia Xie2Yaqin Huang3Jie Tang4Department of Ultrasound, Nanlou Clinic Division, Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinaBeijing Laboratory of Biomedical Material, Beijing University of Chemical Technology, Beijing 100029, ChinaDepartment of Ultrasound, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University, Beijing 102218, ChinaBeijing Laboratory of Biomedical Material, Beijing University of Chemical Technology, Beijing 100029, ChinaDepartment of Ultrasound, Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinaIt is well known that the thrombin obtained from animal is available in clinical treatment, which plays an important role in hemostasis and the treatment of hemorrhagic diseases. However, how to achieve complete hemostasis in 2 min is still a challenge. In this report, the thrombin hemostatic has been improved using the cross-linked gelatin by microbial transglutaminase, and its efficacy was demonstrated by the vitro experiment. Compared with the traditional thrombin hemostatic the clotting time with the improved hemostat is significantly shorter. It may rapidly stop blood loss, which would provide a simple, safe, and cost-effective surgical sealant.http://dx.doi.org/10.1155/2015/985286 |
| spellingShingle | Tengfei Yu Yuepeng Guan Xia Xie Yaqin Huang Jie Tang Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase International Journal of Polymer Science |
| title | Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase |
| title_full | Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase |
| title_fullStr | Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase |
| title_full_unstemmed | Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase |
| title_short | Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase |
| title_sort | improved thrombin hemostat using the cross linked gelatin by microbial transglutaminase |
| url | http://dx.doi.org/10.1155/2015/985286 |
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