Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.

To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock factor 1 (HSF-1), the conserved master regulator of...

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Main Authors: Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W Wingett, Hermine Kienberger, Karin Kleigrewe, Mario de Bono, Michael J O Wakelam, Olivia Casanueva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-11-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001431&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001431&type=printable

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