The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction
Abstract Naïve and memory T cells play a pivotal role in solid tumor pathogenesis but their role in pancreatic cancer progression remains elusive. Thus, we aimed to investigate their clinical potential in advanced pancreatic cancer (APC). Flow cytometry was performed to evaluate the level of baselin...
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Wiley
2019-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1988 |
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| author | Junjie Hang Junjie Huang Siyuan Zhou Lixia Wu Yingwei Zhu Lina Zhu Hanyu Zhou Kequn Xu Hua Jiang Xuguang Yang |
| author_facet | Junjie Hang Junjie Huang Siyuan Zhou Lixia Wu Yingwei Zhu Lina Zhu Hanyu Zhou Kequn Xu Hua Jiang Xuguang Yang |
| author_sort | Junjie Hang |
| collection | DOAJ |
| description | Abstract Naïve and memory T cells play a pivotal role in solid tumor pathogenesis but their role in pancreatic cancer progression remains elusive. Thus, we aimed to investigate their clinical potential in advanced pancreatic cancer (APC). Flow cytometry was performed to evaluate the level of baseline peripheral naïve and memory T cells from 137 APC patients before receiving first‐line chemotherapy. Interrelationships between naïve, memory T cells and clinicopathological variables were evaluated using Pearson’s correlation. The prognostic impact of naïve and memory T cells were assessed by Kaplan‐Meier analysis and Cox regression. The correlation between naïve/memory T cells and tumor progression was investigated by Student’s t test. CD4+ naïve/memory ratio showed close correlations with hemoglobin, red blood cell (RBC), absolute neutrophil count (ANC) and platelet while CD8+ naïve/memory ratio was correlated with hemoglobin, RBC and CEA. Higher baseline lever of CD4+CD45RO+/CD4+ was correlated with better overall survival (OS) (P = 0.036). Patients with CD4+ naïve/memory ratio ≥0.36 had a poorer OS than those with CD4+ naïve/memory ratio <0.36 (P = 0.021). In addition, CD4+ naïve/memory ratio showed independent prognostic impact (HR 1.427, 95% CI 1.033‐1.973, P = 0.031). Furthermore, poorer clinical response was correlated with higher level of CD8+ naïve/memory ratio after the third cycle of chemotherapy (P = 0.01). Besides, patients with a lower level of CD8+ naïve/memory ratio had longer progression‐free survival (PFS) (P = 0.028). We propose CD4+ naïve/memory ratio as a novel prognostic biomarker for APC. In addition, CD8+ naïve/memory ratio can be a candidate marker for predicting PFS and the change of its level may reflect the progression of APC. |
| format | Article |
| id | doaj-art-852b379bdbfd4aeba927b023053a58d9 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-852b379bdbfd4aeba927b023053a58d92025-01-31T08:47:43ZengWileyCancer Medicine2045-76342019-03-01831326133510.1002/cam4.1988The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome predictionJunjie Hang0Junjie Huang1Siyuan Zhou2Lixia Wu3Yingwei Zhu4Lina Zhu5Hanyu Zhou6Kequn Xu7Hua Jiang8Xuguang Yang9Department of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaJC School of Public Health and Primary Care Chinese University of Hong Kong Hong Kong ChinaDepartment of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Oncology Shanghai JingAn District ZhaBei Central Hospital Shanghai ChinaDepartment of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Oncology, Changzhou No.2 People’s Hospital Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu ChinaState Key Laboratory for Oncogenes and Related Genes, Department of Oncology, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaAbstract Naïve and memory T cells play a pivotal role in solid tumor pathogenesis but their role in pancreatic cancer progression remains elusive. Thus, we aimed to investigate their clinical potential in advanced pancreatic cancer (APC). Flow cytometry was performed to evaluate the level of baseline peripheral naïve and memory T cells from 137 APC patients before receiving first‐line chemotherapy. Interrelationships between naïve, memory T cells and clinicopathological variables were evaluated using Pearson’s correlation. The prognostic impact of naïve and memory T cells were assessed by Kaplan‐Meier analysis and Cox regression. The correlation between naïve/memory T cells and tumor progression was investigated by Student’s t test. CD4+ naïve/memory ratio showed close correlations with hemoglobin, red blood cell (RBC), absolute neutrophil count (ANC) and platelet while CD8+ naïve/memory ratio was correlated with hemoglobin, RBC and CEA. Higher baseline lever of CD4+CD45RO+/CD4+ was correlated with better overall survival (OS) (P = 0.036). Patients with CD4+ naïve/memory ratio ≥0.36 had a poorer OS than those with CD4+ naïve/memory ratio <0.36 (P = 0.021). In addition, CD4+ naïve/memory ratio showed independent prognostic impact (HR 1.427, 95% CI 1.033‐1.973, P = 0.031). Furthermore, poorer clinical response was correlated with higher level of CD8+ naïve/memory ratio after the third cycle of chemotherapy (P = 0.01). Besides, patients with a lower level of CD8+ naïve/memory ratio had longer progression‐free survival (PFS) (P = 0.028). We propose CD4+ naïve/memory ratio as a novel prognostic biomarker for APC. In addition, CD8+ naïve/memory ratio can be a candidate marker for predicting PFS and the change of its level may reflect the progression of APC.https://doi.org/10.1002/cam4.1988advanced pancreatic cancermemory T cellsnaïve T cellsprognostic valueprogression prediction |
| spellingShingle | Junjie Hang Junjie Huang Siyuan Zhou Lixia Wu Yingwei Zhu Lina Zhu Hanyu Zhou Kequn Xu Hua Jiang Xuguang Yang The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction Cancer Medicine advanced pancreatic cancer memory T cells naïve T cells prognostic value progression prediction |
| title | The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction |
| title_full | The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction |
| title_fullStr | The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction |
| title_full_unstemmed | The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction |
| title_short | The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction |
| title_sort | clinical implication of cd45ra naive t cells and cd45ro memory t cells in advanced pancreatic cancer a proxy for tumor biology and outcome prediction |
| topic | advanced pancreatic cancer memory T cells naïve T cells prognostic value progression prediction |
| url | https://doi.org/10.1002/cam4.1988 |
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