Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies
The bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells. Cancer stem cells (CSCs), neoplastic cells, hematopoietic stem cells (HSCs), and mesenchymal stromal/stem cells (MSCs) are all components of this micro...
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| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/9863194 |
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| author | Ilaria Laurenzana Daniela Lamorte Stefania Trino Luciana De Luca Concetta Ambrosino Pietro Zoppoli Vitalba Ruggieri Luigi Del Vecchio Pellegrino Musto Antonella Caivano Geppino Falco |
| author_facet | Ilaria Laurenzana Daniela Lamorte Stefania Trino Luciana De Luca Concetta Ambrosino Pietro Zoppoli Vitalba Ruggieri Luigi Del Vecchio Pellegrino Musto Antonella Caivano Geppino Falco |
| author_sort | Ilaria Laurenzana |
| collection | DOAJ |
| description | The bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells. Cancer stem cells (CSCs), neoplastic cells, hematopoietic stem cells (HSCs), and mesenchymal stromal/stem cells (MSCs) are all components of this microenvironment. CSCs are the HM initiators and are associated with neoplastic growth and drug resistance, while HSCs are able to reconstitute the entire hematopoietic system; finally, MSCs actively support hematopoiesis. In some HMs, CSCs and neoplastic cells compromise the normal development of HSCs and perturb BM-MSCs. In response, “reprogrammed” MSCs generate a favorable environment to support neoplastic cells. Extracellular vesicles (EVs) are an important cell-to-cell communication type in physiological and pathological conditions. In particular, in HMs, EV secretion participates to unidirectional and bidirectional interactions between neoplastic cells and BM cells. The transfer of EV molecular cargo triggers different responses in target cells; in particular, malignant EVs modify the BM environment in favor of neoplastic cells at the expense of normal HSCs, by interfering with antineoplastic immunity and participating in resistance to treatment. Here, we review the role of EVs in BM cell communication in physiological conditions and in HMs, focusing on the effects of BM niche EVs on HSCs and MSCs. |
| format | Article |
| id | doaj-art-8521fd63048b478da79390e87cabb38d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8521fd63048b478da79390e87cabb38d2025-02-03T01:33:14ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/98631949863194Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological MalignanciesIlaria Laurenzana0Daniela Lamorte1Stefania Trino2Luciana De Luca3Concetta Ambrosino4Pietro Zoppoli5Vitalba Ruggieri6Luigi Del Vecchio7Pellegrino Musto8Antonella Caivano9Geppino Falco10Laboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalyDepartment of Science and Technology, University of Sannio, Benevento, ItalyLaboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalyCEINGE-Biotecnologie Avanzate s.c. a.r.l., Naples, ItalyScientific Direction, IRCCS-CROB, Rionero in Vulture, ItalyLaboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, ItalySection of Stem Cell and Development, Istituto di Ricerche Genetiche “Gaetano Salvatore” Biogem s.c. a.r.l., Ariano Irpino, ItalyThe bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells. Cancer stem cells (CSCs), neoplastic cells, hematopoietic stem cells (HSCs), and mesenchymal stromal/stem cells (MSCs) are all components of this microenvironment. CSCs are the HM initiators and are associated with neoplastic growth and drug resistance, while HSCs are able to reconstitute the entire hematopoietic system; finally, MSCs actively support hematopoiesis. In some HMs, CSCs and neoplastic cells compromise the normal development of HSCs and perturb BM-MSCs. In response, “reprogrammed” MSCs generate a favorable environment to support neoplastic cells. Extracellular vesicles (EVs) are an important cell-to-cell communication type in physiological and pathological conditions. In particular, in HMs, EV secretion participates to unidirectional and bidirectional interactions between neoplastic cells and BM cells. The transfer of EV molecular cargo triggers different responses in target cells; in particular, malignant EVs modify the BM environment in favor of neoplastic cells at the expense of normal HSCs, by interfering with antineoplastic immunity and participating in resistance to treatment. Here, we review the role of EVs in BM cell communication in physiological conditions and in HMs, focusing on the effects of BM niche EVs on HSCs and MSCs.http://dx.doi.org/10.1155/2018/9863194 |
| spellingShingle | Ilaria Laurenzana Daniela Lamorte Stefania Trino Luciana De Luca Concetta Ambrosino Pietro Zoppoli Vitalba Ruggieri Luigi Del Vecchio Pellegrino Musto Antonella Caivano Geppino Falco Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies Stem Cells International |
| title | Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies |
| title_full | Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies |
| title_fullStr | Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies |
| title_full_unstemmed | Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies |
| title_short | Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies |
| title_sort | extracellular vesicles a new prospective in crosstalk between microenvironment and stem cells in hematological malignancies |
| url | http://dx.doi.org/10.1155/2018/9863194 |
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