A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update
This is a case of a patient who presented to the emergency department with acute abdominal pain due to bowel obstruction. An extended right hemicolectomy with ileosigmoid anastomosis due to an obstructing mass on the splenic flexure was urgently performed. During operation, liver and peritoneal lesi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/4767019 |
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| author | K. Thomopoulou M. Tzardi D. Mavroudis I. Souglakos |
| author_facet | K. Thomopoulou M. Tzardi D. Mavroudis I. Souglakos |
| author_sort | K. Thomopoulou |
| collection | DOAJ |
| description | This is a case of a patient who presented to the emergency department with acute abdominal pain due to bowel obstruction. An extended right hemicolectomy with ileosigmoid anastomosis due to an obstructing mass on the splenic flexure was urgently performed. During operation, liver and peritoneal lesions were detected and samples were also sent for histological analysis. Pathology report was consistent with poorly differentiated mucinous adenocarcinoma with signet ring cells; peritoneal lesions were confirmed histologically as metastatic. Genetic testing revealed the BRAFV600E mutation and mismatch repair deficiency (dMMR). After progressing on 1st line chemotherapy, the patient has a continuing and long-lasting partial response to 2nd line treatment with pembrolizumab. |
| format | Article |
| id | doaj-art-8521b0c846804dd48ecbb12a179f9dc9 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-8521b0c846804dd48ecbb12a179f9dc92025-02-03T01:23:41ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/47670194767019A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography UpdateK. Thomopoulou0M. Tzardi1D. Mavroudis2I. Souglakos3Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, GreeceLaboratory Department of Pathology, Medical School, University of Crete, GreeceDepartment of Medical Oncology, University General Hospital of Heraklion, Heraklion, GreeceDepartment of Medical Oncology, University General Hospital of Heraklion, Heraklion, GreeceThis is a case of a patient who presented to the emergency department with acute abdominal pain due to bowel obstruction. An extended right hemicolectomy with ileosigmoid anastomosis due to an obstructing mass on the splenic flexure was urgently performed. During operation, liver and peritoneal lesions were detected and samples were also sent for histological analysis. Pathology report was consistent with poorly differentiated mucinous adenocarcinoma with signet ring cells; peritoneal lesions were confirmed histologically as metastatic. Genetic testing revealed the BRAFV600E mutation and mismatch repair deficiency (dMMR). After progressing on 1st line chemotherapy, the patient has a continuing and long-lasting partial response to 2nd line treatment with pembrolizumab.http://dx.doi.org/10.1155/2019/4767019 |
| spellingShingle | K. Thomopoulou M. Tzardi D. Mavroudis I. Souglakos A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update Case Reports in Oncological Medicine |
| title | A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update |
| title_full | A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update |
| title_fullStr | A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update |
| title_full_unstemmed | A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update |
| title_short | A Case Presentation of a Patient with Microsatellite Instability and BRAF Mutant Metastatic Colon Cancer and Bibliography Update |
| title_sort | case presentation of a patient with microsatellite instability and braf mutant metastatic colon cancer and bibliography update |
| url | http://dx.doi.org/10.1155/2019/4767019 |
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