Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution
Background: The relationship between tumour necrosis factor (TNF) levels and disease progression is well-established. However, the impact of changes in the level of TNF hydrolase (A-disintegrin and metalloenzyme 17; ADAM17) in HIV patients remains to be fully elucidated. Methods: Between March 1 and...
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Elsevier
2024-12-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024167655 |
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| author | Ying Lin Ming Chen Xuelian Zhu xiaoya cui Suyu Sun Xingzhong Hu |
| author_facet | Ying Lin Ming Chen Xuelian Zhu xiaoya cui Suyu Sun Xingzhong Hu |
| author_sort | Ying Lin |
| collection | DOAJ |
| description | Background: The relationship between tumour necrosis factor (TNF) levels and disease progression is well-established. However, the impact of changes in the level of TNF hydrolase (A-disintegrin and metalloenzyme 17; ADAM17) in HIV patients remains to be fully elucidated. Methods: Between March 1 and December 31, 2017, data were collected from 64 HIV-positive individuals in Wenzhou. Based on their history of antiviral treatment at the time of enrollment, these patients were categorized into two cohorts: an antiviral-treated group and an untreated HIV group. Then, the serum ADAM17 levels of each group were measured and analysed. Results: In comparison to the antiviral-treated group and the control group, the untreated HIV group exhibited a significantly elevated serum ADAM17 level (p < 0.001). A significant negative correlation was observed between serum ADAM17 levels and CD4+ T cell counts in the untreated HIV group (r = −0.486, p = 0.001). ROC curve analysis revealed that the pre-treatment serum ADAM17 level in the untreated HIV group had moderate diagnostic accuracy for the AIDS stage (area under the curve: 0.703, p = 0.028). Additionally, serum ADAM17 levels were positively correlated with ADAM17 expression on the surface of leukocytes (r = 0.367, p = 0.018). Conclusion: Serum ADAM17 levels are significantly elevated in HIV patients and are correlated with disease progression and immune reconstitution. |
| format | Article |
| id | doaj-art-851c2ad3a3eb482580cca2b9807bccd2 |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| spelling | doaj-art-851c2ad3a3eb482580cca2b9807bccd22025-08-20T02:38:15ZengElsevierHeliyon2405-84402024-12-011023e4073410.1016/j.heliyon.2024.e40734Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitutionYing Lin0Ming Chen1Xuelian Zhu2 xiaoya cui3Suyu Sun4Xingzhong Hu5Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou, 325000, ChinaThe Third Affiliated Hospital of Wenzhou Medical University, Ruian 325200, Zhejiang, ChinaDingli Clinical School of Wenzhou Medical University, Wenzhou, 325000, ChinaDepartment of Infectious Diseases, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou, 325000, ChinaGynaecology and obstetrics, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou, 325000, China; Corresponding author.Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou, 325000, China; Corresponding author.Background: The relationship between tumour necrosis factor (TNF) levels and disease progression is well-established. However, the impact of changes in the level of TNF hydrolase (A-disintegrin and metalloenzyme 17; ADAM17) in HIV patients remains to be fully elucidated. Methods: Between March 1 and December 31, 2017, data were collected from 64 HIV-positive individuals in Wenzhou. Based on their history of antiviral treatment at the time of enrollment, these patients were categorized into two cohorts: an antiviral-treated group and an untreated HIV group. Then, the serum ADAM17 levels of each group were measured and analysed. Results: In comparison to the antiviral-treated group and the control group, the untreated HIV group exhibited a significantly elevated serum ADAM17 level (p < 0.001). A significant negative correlation was observed between serum ADAM17 levels and CD4+ T cell counts in the untreated HIV group (r = −0.486, p = 0.001). ROC curve analysis revealed that the pre-treatment serum ADAM17 level in the untreated HIV group had moderate diagnostic accuracy for the AIDS stage (area under the curve: 0.703, p = 0.028). Additionally, serum ADAM17 levels were positively correlated with ADAM17 expression on the surface of leukocytes (r = 0.367, p = 0.018). Conclusion: Serum ADAM17 levels are significantly elevated in HIV patients and are correlated with disease progression and immune reconstitution.http://www.sciencedirect.com/science/article/pii/S2405844024167655ADAM17HIVCD4+ T cells |
| spellingShingle | Ying Lin Ming Chen Xuelian Zhu xiaoya cui Suyu Sun Xingzhong Hu Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution Heliyon ADAM17 HIV CD4+ T cells |
| title | Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution |
| title_full | Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution |
| title_fullStr | Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution |
| title_full_unstemmed | Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution |
| title_short | Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution |
| title_sort | serum adam17 levels pre antiviral therapy correlate with hiv patient immune reconstitution |
| topic | ADAM17 HIV CD4+ T cells |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024167655 |
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