Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial
Abstract Background: Postoperative pain management has been found to reduce postoperative morbidity, length of hospital stays, and overall healthcare cost and increased patient satisfaction. There is currently no gold standard for pain management in the immediate postoperative period following cesar...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-04-01
|
| Series: | Bali Journal of Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.4103/bjoa.bjoa_53_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586518742433792 |
|---|---|
| author | Julian Ojebo Joseph Achi Ifeanyichukwu Michael Chukwu Osadebamen Mercy Oboh Benedict Ezeife Aisha Sanusi Muazu Christian Osemudiamen Igibah Salami Ezekiel Kelvin |
| author_facet | Julian Ojebo Joseph Achi Ifeanyichukwu Michael Chukwu Osadebamen Mercy Oboh Benedict Ezeife Aisha Sanusi Muazu Christian Osemudiamen Igibah Salami Ezekiel Kelvin |
| author_sort | Julian Ojebo |
| collection | DOAJ |
| description | Abstract Background: Postoperative pain management has been found to reduce postoperative morbidity, length of hospital stays, and overall healthcare cost and increased patient satisfaction. There is currently no gold standard for pain management in the immediate postoperative period following cesarean section. The goal of this study was to assess the effectiveness of nefopam for postoperative pain management in cesarean section compared with pethidine. Materials and Methods: A total of 144 ASA II and III pregnant women scheduled for cesarean section under spinal anesthesia were recruited in the study. The two groups of patients were randomly assigned, receiving either nefopam-dexamethasone (group N) or pethidine-dexamethasone (group P). The measured outcomes were pain scores measured by the numeric rating scale (NRS), time to first analgesic request, side effects. Results: The demographic properties of the patients were comparable. No patients reported moderate or worse pain. Patients in group N reported lower NRS scores compared with group P. However, the differences were not statistically significant. Moreover, the time to first analgesic request was 315.18 ± 103.61 min in group N and 286.86 ± 101.79 min in group P (P = 0.100). No side effects were noted in this study. Conclusion: The combination of nefopam and dexamethasone is equipotent to the combination of pethidine and dexamethasone in pain control after cesarean section and can be proposed as an alternative to opioids postoperatively. |
| format | Article |
| id | doaj-art-85152e0b62764109bf11185f1a53ed28 |
| institution | Kabale University |
| issn | 2549-2276 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Bali Journal of Anesthesiology |
| spelling | doaj-art-85152e0b62764109bf11185f1a53ed282025-01-25T09:57:50ZengWolters Kluwer Medknow PublicationsBali Journal of Anesthesiology2549-22762024-04-018210510910.4103/bjoa.bjoa_53_24Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trialJulian OjeboJoseph AchiIfeanyichukwu Michael ChukwuOsadebamen Mercy ObohBenedict EzeifeAisha Sanusi MuazuChristian Osemudiamen IgibahSalami Ezekiel KelvinAbstract Background: Postoperative pain management has been found to reduce postoperative morbidity, length of hospital stays, and overall healthcare cost and increased patient satisfaction. There is currently no gold standard for pain management in the immediate postoperative period following cesarean section. The goal of this study was to assess the effectiveness of nefopam for postoperative pain management in cesarean section compared with pethidine. Materials and Methods: A total of 144 ASA II and III pregnant women scheduled for cesarean section under spinal anesthesia were recruited in the study. The two groups of patients were randomly assigned, receiving either nefopam-dexamethasone (group N) or pethidine-dexamethasone (group P). The measured outcomes were pain scores measured by the numeric rating scale (NRS), time to first analgesic request, side effects. Results: The demographic properties of the patients were comparable. No patients reported moderate or worse pain. Patients in group N reported lower NRS scores compared with group P. However, the differences were not statistically significant. Moreover, the time to first analgesic request was 315.18 ± 103.61 min in group N and 286.86 ± 101.79 min in group P (P = 0.100). No side effects were noted in this study. Conclusion: The combination of nefopam and dexamethasone is equipotent to the combination of pethidine and dexamethasone in pain control after cesarean section and can be proposed as an alternative to opioids postoperatively.https://doi.org/10.4103/bjoa.bjoa_53_24cesarean sectionintravenous dexamethasonenefopampain managementpethidinepostoperative pain |
| spellingShingle | Julian Ojebo Joseph Achi Ifeanyichukwu Michael Chukwu Osadebamen Mercy Oboh Benedict Ezeife Aisha Sanusi Muazu Christian Osemudiamen Igibah Salami Ezekiel Kelvin Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial Bali Journal of Anesthesiology cesarean section intravenous dexamethasone nefopam pain management pethidine postoperative pain |
| title | Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial |
| title_full | Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial |
| title_fullStr | Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial |
| title_full_unstemmed | Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial |
| title_short | Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial |
| title_sort | effectiveness of nefopam dexamethasone versus pethidine dexamethasone for postoperative pain management in cesarean sections a double blind prospective clinical trial |
| topic | cesarean section intravenous dexamethasone nefopam pain management pethidine postoperative pain |
| url | https://doi.org/10.4103/bjoa.bjoa_53_24 |
| work_keys_str_mv | AT julianojebo effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT josephachi effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT ifeanyichukwumichaelchukwu effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT osadebamenmercyoboh effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT benedictezeife effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT aishasanusimuazu effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT christianosemudiamenigibah effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial AT salamiezekielkelvin effectivenessofnefopamdexamethasoneversuspethidinedexamethasoneforpostoperativepainmanagementincesareansectionsadoubleblindprospectiveclinicaltrial |