Transcriptional Regulators of Claudins in Epithelial Tight Junctions
Human gastrointestinal tract is covered by a monolayer of specialized epithelial cells that constitute a protective barrier surface to external toxic and infectious agents along with metabolic and digestive functions. Intercellular junctions, among epithelial cells, such as desmosomes, adherens, gap...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/219843 |
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| author | Niamat Khan Abdul R. Asif |
| author_facet | Niamat Khan Abdul R. Asif |
| author_sort | Niamat Khan |
| collection | DOAJ |
| description | Human gastrointestinal tract is covered by a monolayer of specialized epithelial cells that constitute a protective barrier surface to external toxic and infectious agents along with metabolic and digestive functions. Intercellular junctions, among epithelial cells, such as desmosomes, adherens, gap, and tight junctions (TJs), not only provide mechanical integrity but also limit movement of molecules across the monolayer. TJ is a complex structure composed of approximately 35 different proteins that interact with each other at the apical side of two adjacent epithelial cells. Claudin family proteins are important members of TJ with so far 24 known isoforms in different species. Claudins are structural proteins of TJ that help to control the paracellular movement by forming fence and barrier across the epithelial monolayer. Altered function of claudins is implicated in different form of cancers, inflammatory bowel diseases (IBDs), and leaky diarrhea. Based on their significant role in the molecular architecture of TJ, diversity, and disease association, further understanding about claudin family proteins and their genetic/epigenetic regulators is indispensable. |
| format | Article |
| id | doaj-art-85135af3b74c4aef8d987638080a9f24 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-85135af3b74c4aef8d987638080a9f242025-02-03T01:23:42ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/219843219843Transcriptional Regulators of Claudins in Epithelial Tight JunctionsNiamat Khan0Abdul R. Asif1Institute for Clinical Chemistry/UMG-Laboratories, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, GermanyInstitute for Clinical Chemistry/UMG-Laboratories, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, GermanyHuman gastrointestinal tract is covered by a monolayer of specialized epithelial cells that constitute a protective barrier surface to external toxic and infectious agents along with metabolic and digestive functions. Intercellular junctions, among epithelial cells, such as desmosomes, adherens, gap, and tight junctions (TJs), not only provide mechanical integrity but also limit movement of molecules across the monolayer. TJ is a complex structure composed of approximately 35 different proteins that interact with each other at the apical side of two adjacent epithelial cells. Claudin family proteins are important members of TJ with so far 24 known isoforms in different species. Claudins are structural proteins of TJ that help to control the paracellular movement by forming fence and barrier across the epithelial monolayer. Altered function of claudins is implicated in different form of cancers, inflammatory bowel diseases (IBDs), and leaky diarrhea. Based on their significant role in the molecular architecture of TJ, diversity, and disease association, further understanding about claudin family proteins and their genetic/epigenetic regulators is indispensable.http://dx.doi.org/10.1155/2015/219843 |
| spellingShingle | Niamat Khan Abdul R. Asif Transcriptional Regulators of Claudins in Epithelial Tight Junctions Mediators of Inflammation |
| title | Transcriptional Regulators of Claudins in Epithelial Tight Junctions |
| title_full | Transcriptional Regulators of Claudins in Epithelial Tight Junctions |
| title_fullStr | Transcriptional Regulators of Claudins in Epithelial Tight Junctions |
| title_full_unstemmed | Transcriptional Regulators of Claudins in Epithelial Tight Junctions |
| title_short | Transcriptional Regulators of Claudins in Epithelial Tight Junctions |
| title_sort | transcriptional regulators of claudins in epithelial tight junctions |
| url | http://dx.doi.org/10.1155/2015/219843 |
| work_keys_str_mv | AT niamatkhan transcriptionalregulatorsofclaudinsinepithelialtightjunctions AT abdulrasif transcriptionalregulatorsofclaudinsinepithelialtightjunctions |