Placenta crucially affects formation of fetal congenital heart disease
It has been increasingly recognized that structural abnormalities and functional changes in the placenta can adversely affect developing fetal heart. In this article, we examine a role of the placenta as well as potential impact of placental insufficiency on a fetus with congenital heart disease (CH...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-03-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1242 |
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| author | V. I. Tsibizova T. M. Pervunina V. A. Artemenko V. O. Bitsadze K. E. Gotsiridze I. I. Averkin D. V. Blinov N. Yu. Novikova |
| author_facet | V. I. Tsibizova T. M. Pervunina V. A. Artemenko V. O. Bitsadze K. E. Gotsiridze I. I. Averkin D. V. Blinov N. Yu. Novikova |
| author_sort | V. I. Tsibizova |
| collection | DOAJ |
| description | It has been increasingly recognized that structural abnormalities and functional changes in the placenta can adversely affect developing fetal heart. In this article, we examine a role of the placenta as well as potential impact of placental insufficiency on a fetus with congenital heart disease (CHD). The fetal heart and placenta are directly connected because they develop simultaneously with common regulatory and signaling pathways. Moreover, placenta-associated complications are more common in pregnant women carrying fetus with CHD, and the fetal response to placental insufficiency may lead to postnatal preservation of remodeled heart. The mechanisms underlying this placenta–fetus axis potentially consists of genetic factors, oxidative stress, chronic hypoxia, and/or angiogenic imbalance. Thus, the mother–placenta–fetus circulation is critical in understanding the CHD formation. It is necessary to study the changing factors involved in these processes for early identification, imaging, quantification of placental insufficiency, and development of new prenatal therapies in the CHD patient population. |
| format | Article |
| id | doaj-art-850d50f5da0449b083b133473f0e8e3c |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2022-03-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-850d50f5da0449b083b133473f0e8e3c2025-08-20T03:19:14ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942022-03-01161667210.17749/2313-7347/ob.gyn.rep.2022.262708Placenta crucially affects formation of fetal congenital heart diseaseV. I. Tsibizova0T. M. Pervunina1V. A. Artemenko2V. O. Bitsadze3K. E. Gotsiridze4I. I. Averkin5D. V. Blinov6N. Yu. Novikova7Almazov National Medical Research Centre, Health Ministry of Russian FederationAlmazov National Medical Research Centre, Health Ministry of Russian FederationAlmazov National Medical Research Centre, Health Ministry of Russian FederationSechenov UniversityChachava ClinicAlmazov National Medical Research Centre, Health Ministry of Russian FederationInstitute for Preventive and Social Medicine; Lapino Clinical Hospital, GC «Mother and Child»Mechnikov North-Western State Medical University, Health Ministry of Russian FederationIt has been increasingly recognized that structural abnormalities and functional changes in the placenta can adversely affect developing fetal heart. In this article, we examine a role of the placenta as well as potential impact of placental insufficiency on a fetus with congenital heart disease (CHD). The fetal heart and placenta are directly connected because they develop simultaneously with common regulatory and signaling pathways. Moreover, placenta-associated complications are more common in pregnant women carrying fetus with CHD, and the fetal response to placental insufficiency may lead to postnatal preservation of remodeled heart. The mechanisms underlying this placenta–fetus axis potentially consists of genetic factors, oxidative stress, chronic hypoxia, and/or angiogenic imbalance. Thus, the mother–placenta–fetus circulation is critical in understanding the CHD formation. It is necessary to study the changing factors involved in these processes for early identification, imaging, quantification of placental insufficiency, and development of new prenatal therapies in the CHD patient population.https://www.gynecology.su/jour/article/view/1242congenital heart diseaseschdvascular endothelial growth factorvegfsoluble fms-like tyrosine kinase-1sflt-1placental growth factorplgf |
| spellingShingle | V. I. Tsibizova T. M. Pervunina V. A. Artemenko V. O. Bitsadze K. E. Gotsiridze I. I. Averkin D. V. Blinov N. Yu. Novikova Placenta crucially affects formation of fetal congenital heart disease Акушерство, гинекология и репродукция congenital heart diseases chd vascular endothelial growth factor vegf soluble fms-like tyrosine kinase-1 sflt-1 placental growth factor plgf |
| title | Placenta crucially affects formation of fetal congenital heart disease |
| title_full | Placenta crucially affects formation of fetal congenital heart disease |
| title_fullStr | Placenta crucially affects formation of fetal congenital heart disease |
| title_full_unstemmed | Placenta crucially affects formation of fetal congenital heart disease |
| title_short | Placenta crucially affects formation of fetal congenital heart disease |
| title_sort | placenta crucially affects formation of fetal congenital heart disease |
| topic | congenital heart diseases chd vascular endothelial growth factor vegf soluble fms-like tyrosine kinase-1 sflt-1 placental growth factor plgf |
| url | https://www.gynecology.su/jour/article/view/1242 |
| work_keys_str_mv | AT vitsibizova placentacruciallyaffectsformationoffetalcongenitalheartdisease AT tmpervunina placentacruciallyaffectsformationoffetalcongenitalheartdisease AT vaartemenko placentacruciallyaffectsformationoffetalcongenitalheartdisease AT vobitsadze placentacruciallyaffectsformationoffetalcongenitalheartdisease AT kegotsiridze placentacruciallyaffectsformationoffetalcongenitalheartdisease AT iiaverkin placentacruciallyaffectsformationoffetalcongenitalheartdisease AT dvblinov placentacruciallyaffectsformationoffetalcongenitalheartdisease AT nyunovikova placentacruciallyaffectsformationoffetalcongenitalheartdisease |