Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation
A retrospective study of central nervous system (CNS) in 284 autopsy AIDS cases in Brazil (1989–2008) divided into 3 groups: A (without antiretroviral treatment: 163 cases); B (other antiretroviral therapies: 76 cases); C (HAART for 3 months or more: 45 cases). In 165 (58.1%) cases, relevant lesions...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/186850 |
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| author | Ana Cristina Araújo Lemos Silva Blenda Sousa Carli Rodrigues Adilha Misson Rua Micheletti Sebastião Tostes Antonio Carlos Oliveira Meneses Mário Leon Silva-Vergara Sheila Jorge Adad |
| author_facet | Ana Cristina Araújo Lemos Silva Blenda Sousa Carli Rodrigues Adilha Misson Rua Micheletti Sebastião Tostes Antonio Carlos Oliveira Meneses Mário Leon Silva-Vergara Sheila Jorge Adad |
| author_sort | Ana Cristina Araújo Lemos Silva |
| collection | DOAJ |
| description | A retrospective study of central nervous system (CNS) in 284 autopsy AIDS cases in Brazil (1989–2008) divided into 3 groups: A (without antiretroviral treatment: 163 cases); B (other antiretroviral therapies: 76 cases); C (HAART for 3 months or more: 45 cases). In 165 (58.1%) cases, relevant lesions were found, predominantly infections (54.2%); the most frequent was toxoplasmosis (29.9%) followed by cryptococcosis (15.8%), purulent bacterial infections (3.9%), and HIV encephalitis (2.8%); non-Hodgkin lymphomas occurred in 1.4% and vascular lesions in 1.1%. There was no difference when compared the frequency of lesion among the groups; however, toxoplasmosis was less common while HIV encephalitis was more frequent in group C related to A. CNS lesions remain a frequent cause of death in AIDS; however, the mean survival time was four times greater in group C than in A. In 91 (55.1%) of 165 cases with relevant brain lesions (or 32% of the total 284 cases), there was discordance between pre- and postmortem diagnosis; disagreement type 1 (important disease that if diagnosed in life could change the patient prognosis) occurred in 49 (53.8%) of 91 discordant cases (17.6% of the total 284) indicating the autopsy importance, even with HAART and advanced diagnostics technologies. |
| format | Article |
| id | doaj-art-84f31ef727914d39b13c23ea7a6a94f6 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-84f31ef727914d39b13c23ea7a6a94f62025-02-03T06:07:22ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/186850186850Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem CorrelationAna Cristina Araújo Lemos Silva0Blenda Sousa Carli Rodrigues1Adilha Misson Rua Micheletti2Sebastião Tostes3Antonio Carlos Oliveira Meneses4Mário Leon Silva-Vergara5Sheila Jorge Adad6Discipline of Special Pathology, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, 38025-440 Uberaba, MG, BrazilScientific Initiation Scholarship, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), UFTM, 38025-440 Uberaba, MG, BrazilDiscipline of Special Pathology, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, 38025-440 Uberaba, MG, BrazilDiscipline of Forensic Medicine, UFTM, Avenida Getúlio Guaritá 130, 38025-440 Uberaba, MG, BrazilDiscipline of Special Pathology, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, 38025-440 Uberaba, MG, BrazilDiscipline of Infectious and Parasitic Diseases, UFTM, Avenida Getúlio Guaritá 130, 38025-440 Uberaba, MG, BrazilDiscipline of Special Pathology, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, 38025-440 Uberaba, MG, BrazilA retrospective study of central nervous system (CNS) in 284 autopsy AIDS cases in Brazil (1989–2008) divided into 3 groups: A (without antiretroviral treatment: 163 cases); B (other antiretroviral therapies: 76 cases); C (HAART for 3 months or more: 45 cases). In 165 (58.1%) cases, relevant lesions were found, predominantly infections (54.2%); the most frequent was toxoplasmosis (29.9%) followed by cryptococcosis (15.8%), purulent bacterial infections (3.9%), and HIV encephalitis (2.8%); non-Hodgkin lymphomas occurred in 1.4% and vascular lesions in 1.1%. There was no difference when compared the frequency of lesion among the groups; however, toxoplasmosis was less common while HIV encephalitis was more frequent in group C related to A. CNS lesions remain a frequent cause of death in AIDS; however, the mean survival time was four times greater in group C than in A. In 91 (55.1%) of 165 cases with relevant brain lesions (or 32% of the total 284 cases), there was discordance between pre- and postmortem diagnosis; disagreement type 1 (important disease that if diagnosed in life could change the patient prognosis) occurred in 49 (53.8%) of 91 discordant cases (17.6% of the total 284) indicating the autopsy importance, even with HAART and advanced diagnostics technologies.http://dx.doi.org/10.1155/2012/186850 |
| spellingShingle | Ana Cristina Araújo Lemos Silva Blenda Sousa Carli Rodrigues Adilha Misson Rua Micheletti Sebastião Tostes Antonio Carlos Oliveira Meneses Mário Leon Silva-Vergara Sheila Jorge Adad Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation AIDS Research and Treatment |
| title | Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation |
| title_full | Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation |
| title_fullStr | Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation |
| title_full_unstemmed | Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation |
| title_short | Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation |
| title_sort | neuropathology of aids an autopsy review of 284 cases from brazil comparing the findings pre and post haart highly active antiretroviral therapy and pre and postmortem correlation |
| url | http://dx.doi.org/10.1155/2012/186850 |
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