Advances in the treatment of lower limb ischemic diseases with exosomes: A systematic review
Extracellular vesicles sare double-layered phospholipid-coated spherical particles released by all cells, primarily classified into microvesicles, exosomes, and apoptotic vesicles. Exosomes contain various cellular components and play crucial roles in tissue regeneration and intercellular signaling....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Vascular Investigation and Therapy |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/vit.VIT-D-25-00003 |
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| Summary: | Extracellular vesicles sare double-layered phospholipid-coated spherical particles released by all cells, primarily classified into microvesicles, exosomes, and apoptotic vesicles. Exosomes contain various cellular components and play crucial roles in tissue regeneration and intercellular signaling. Lower extremity arterial ischemic diseases, including chronic critical limb ischemia and acute limb ischemia, present severe symptoms and poor prognosis, necessitating new therapeutic approaches. Recent studies indicate that exosomes exhibit therapeutic effects in ischemic diseases, particularly in promoting tissue repair. This article reviews the production, isolation methods, and roles of exosomes in arterial thrombosis and atherosclerosis, highlighting their potential to regulate inflammation, promote vascular regeneration, and serve as biomarkers. Overall, exosomes may emerge as novel therapeutic targets for predicting and monitoring thrombotic disorders, revealing promising applications in atherosclerotic treatment. |
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| ISSN: | 2589-9686 2589-9481 |