Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model
Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer’s disease (AD). However, it is unclear whether different mouse models with mitochondrial-related diseases have similar changes in mitochondrial morphology of the same tissues....
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000095 |
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| author | Min Wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao Maojin Yao Jiaoyan Ren |
| author_facet | Min Wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao Maojin Yao Jiaoyan Ren |
| author_sort | Min Wang |
| collection | DOAJ |
| description | Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer’s disease (AD). However, it is unclear whether different mouse models with mitochondrial-related diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APPSWE/PS1ΔE9 transgenic mouse were examined using transmission electron microscope (TEM). Both young Slc25a46 knockout mice and aged APPSWE/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD. |
| format | Article |
| id | doaj-art-84e77cfc13a3454d9cb177c4e19fdf91 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-84e77cfc13a3454d9cb177c4e19fdf912025-02-03T05:13:48ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112516181625Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse modelMin Wang0Tianxiong Xu1Li Gao2Chujun Huang3Piao Xu4Congcong Gong5William Kwame Amakye6Linfeng Liao7Maojin Yao8Jiaoyan Ren9School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaGuangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Corresponding author at: School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer’s disease (AD). However, it is unclear whether different mouse models with mitochondrial-related diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APPSWE/PS1ΔE9 transgenic mouse were examined using transmission electron microscope (TEM). Both young Slc25a46 knockout mice and aged APPSWE/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD.http://www.sciencedirect.com/science/article/pii/S2213453023000095Mitochondria dysfunctionAgeingSlc25a46 knockout mouseAlzheimer’s diseaseLycium ruthenicum Murr |
| spellingShingle | Min Wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao Maojin Yao Jiaoyan Ren Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model Food Science and Human Wellness Mitochondria dysfunction Ageing Slc25a46 knockout mouse Alzheimer’s disease Lycium ruthenicum Murr |
| title | Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model |
| title_full | Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model |
| title_fullStr | Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model |
| title_full_unstemmed | Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model |
| title_short | Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model |
| title_sort | lycium ruthenicum murr treatment attenuates appswe ps1δe9 mouse model like mitochondrial dysfunction in slc25a46 knockout mouse model |
| topic | Mitochondria dysfunction Ageing Slc25a46 knockout mouse Alzheimer’s disease Lycium ruthenicum Murr |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000095 |
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