5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination

5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination

Introduction: Excessive immune activation induces tissue damage during infection. Compared to external strategies to reconstruct immune homeostasis, host balancing ways remain largely unclear. Objectives: Here we found a neuroimmune way that prevents infection-induced tissue damage. Methods: By FACS...

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Main Authors: Zhenfang Gao, Yang Gao, Yuxiang Li, Jie Zhou, Ge Li, Shun Xie, Ruiyan Jia, Lanying Wang, Ziying Jiang, Meng Liang, Chunxiao Du, Yaqiong Chen, Yinji Liu, Lin Du, Cong Wang, Shuaijie Dou, Zhonglin Lv, Lubin Wang, Renxi Wang, Beifen Shen, Zhiding Wang, Yunfeng Li, Gencheng Han
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Advanced Research
Subjects:
5-HT7R
Meningitis
Neuroimmune
Ubiquitination
CCR5
STUB1
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224000791
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