Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation
Chelation therapy is currently successfully applied to reduce the aluminum burden and its neurodegenerative consequences. In view of a possible application to aluminum chelation therapy, here we have studied the complexation of hydroxybenzoic acids, namely, vanillic, syringic and gallic acids, towar...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/13/1/2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588354816835584 |
|---|---|
| author | Donatella Aiello Tiziana Marino Anna Napoli Emilia Furia Pierluigi Plastina |
| author_facet | Donatella Aiello Tiziana Marino Anna Napoli Emilia Furia Pierluigi Plastina |
| author_sort | Donatella Aiello |
| collection | DOAJ |
| description | Chelation therapy is currently successfully applied to reduce the aluminum burden and its neurodegenerative consequences. In view of a possible application to aluminum chelation therapy, here we have studied the complexation of hydroxybenzoic acids, namely, vanillic, syringic and gallic acids, towards aluminum ion at physiologically relevant conditions as regards temperature (37 °C) and ionic strength (i.e., 0.16 M NaCl). The solubility values and the protonation constants of the hydroxybenzoic acids were primarily assessed to estimate the competition of these acids towards aluminum and H<sup>+</sup> ions. Then, potentiometric titrations were carried out, and the speciation analysis indicated a pH-dependent complexation occurring at a 1:1 hydroxybenzoic acid-to-aluminum ratio for vanillic and syringic, and 1:1, 2:1 and 3:1 ligand-to-Al(III) ratios for gallic. Gallic acid forms more stable complexes with Al(III) ion than vanillic and syringic acids and could therefore represent a good candidate for being used as sequestering agents for Al(III) ion. |
| format | Article |
| id | doaj-art-84cc4e2e3ab94440a0dcbdc8293b1d49 |
| institution | Kabale University |
| issn | 2304-6740 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj-art-84cc4e2e3ab94440a0dcbdc8293b1d492025-01-24T13:35:27ZengMDPI AGInorganics2304-67402024-12-01131210.3390/inorganics13010002Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum CationDonatella Aiello0Tiziana Marino1Anna Napoli2Emilia Furia3Pierluigi Plastina4Department of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, CS, ItalyDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, CS, ItalyDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, CS, ItalyDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, CS, ItalyDepartment of Pharmacy and Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, ItalyChelation therapy is currently successfully applied to reduce the aluminum burden and its neurodegenerative consequences. In view of a possible application to aluminum chelation therapy, here we have studied the complexation of hydroxybenzoic acids, namely, vanillic, syringic and gallic acids, towards aluminum ion at physiologically relevant conditions as regards temperature (37 °C) and ionic strength (i.e., 0.16 M NaCl). The solubility values and the protonation constants of the hydroxybenzoic acids were primarily assessed to estimate the competition of these acids towards aluminum and H<sup>+</sup> ions. Then, potentiometric titrations were carried out, and the speciation analysis indicated a pH-dependent complexation occurring at a 1:1 hydroxybenzoic acid-to-aluminum ratio for vanillic and syringic, and 1:1, 2:1 and 3:1 ligand-to-Al(III) ratios for gallic. Gallic acid forms more stable complexes with Al(III) ion than vanillic and syringic acids and could therefore represent a good candidate for being used as sequestering agents for Al(III) ion.https://www.mdpi.com/2304-6740/13/1/2aluminum cationhydroxybenzoic acidspH-dependent complexationpotentiometry |
| spellingShingle | Donatella Aiello Tiziana Marino Anna Napoli Emilia Furia Pierluigi Plastina Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation Inorganics aluminum cation hydroxybenzoic acids pH-dependent complexation potentiometry |
| title | Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation |
| title_full | Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation |
| title_fullStr | Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation |
| title_full_unstemmed | Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation |
| title_short | Evaluation of Solubility and Complexation Ability of Vanillic, Syringic and Gallic Acids Towards Aluminum Cation |
| title_sort | evaluation of solubility and complexation ability of vanillic syringic and gallic acids towards aluminum cation |
| topic | aluminum cation hydroxybenzoic acids pH-dependent complexation potentiometry |
| url | https://www.mdpi.com/2304-6740/13/1/2 |
| work_keys_str_mv | AT donatellaaiello evaluationofsolubilityandcomplexationabilityofvanillicsyringicandgallicacidstowardsaluminumcation AT tizianamarino evaluationofsolubilityandcomplexationabilityofvanillicsyringicandgallicacidstowardsaluminumcation AT annanapoli evaluationofsolubilityandcomplexationabilityofvanillicsyringicandgallicacidstowardsaluminumcation AT emiliafuria evaluationofsolubilityandcomplexationabilityofvanillicsyringicandgallicacidstowardsaluminumcation AT pierluigiplastina evaluationofsolubilityandcomplexationabilityofvanillicsyringicandgallicacidstowardsaluminumcation |