Solving the RNA design problem with reinforcement learning.

We use reinforcement learning to train an agent for computational RNA design: given a target secondary structure, design a sequence that folds to that structure in silico. Our agent uses a novel graph convolutional architecture allowing a single model to be applied to arbitrary target structures of...

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Bibliographic Details
Main Authors: Peter Eastman, Jade Shi, Bharath Ramsundar, Vijay S Pande
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006176&type=printable
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