Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration
Purpose. Evaluate the relationship between retinal vascular caliber and age-related macular degeneration (AMD) severity or progression. Methods. A retrospective secondary analysis of 1172 fundus photographs and clinical data from the prospective Age-Related Eye Disease Study (AREDS). Central retinal...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/8210599 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554715612708864 |
|---|---|
| author | Sara Toulouie Sean Chang Julia Pan Kiersten Snyder Glenn Yiu |
| author_facet | Sara Toulouie Sean Chang Julia Pan Kiersten Snyder Glenn Yiu |
| author_sort | Sara Toulouie |
| collection | DOAJ |
| description | Purpose. Evaluate the relationship between retinal vascular caliber and age-related macular degeneration (AMD) severity or progression. Methods. A retrospective secondary analysis of 1172 fundus photographs and clinical data from the prospective Age-Related Eye Disease Study (AREDS). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole-to-venule ratio (AVR) were measured using the Parr–Hubbard–Knudtson formula. Univariate and multivariate regressions were used to determine the association of CRAE, CRVE, and AVR with age, sex, smoking status, presence of cilioretinal artery, and AMD severity at baseline and 5 years using the 9-step AMD severity score. Results. Only CRAE and CRVE were higher in men (P<0.001), current smokers (P<0.001), and the eyes with a cilioretinal artery (P=0.009−0.043). AMD severity was greater in older patients (P=0.001), current smokers (P=0.012), the eyes without a cilioretinal artery (P=0.001), and lower AVR (P=0.034) on multivariate regression but was not influenced by CRAE or CRVE (P=0.240−0.500). Choroidal neovascularization (CNV) presence was associated with older age (P=0.003) and absence of a cilioretinal artery (P=0.009), while central geographic atrophy (CGA) was associated with narrower CRAE (P=0.002) and possibly AVR (P=0.046). None of the retinal vessel parameters were predictive of AMD severity score or new onset of CNV or CGA at 5 years. Conclusion. A lower arteriole-to-venule ratio may be associated with AMD severity, with narrower arterioles seen in the eyes with geographic atrophy, suggesting a role of the retinal vasculature in AMD pathophysiology. This trial is registered with ClinicalTrials.gov Identifier: NCT00000145. |
| format | Article |
| id | doaj-art-84c3e6cb8dd643788705ce37ec33844a |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-84c3e6cb8dd643788705ce37ec33844a2025-02-03T05:50:44ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/8210599Relationship of Retinal Vessel Caliber with Age-Related Macular DegenerationSara Toulouie0Sean Chang1Julia Pan2Kiersten Snyder3Glenn Yiu4Department of Ophthalmology & Vision ScienceDepartment of Ophthalmology & Vision ScienceDepartment of Ophthalmology & Vision ScienceDepartment of Ophthalmology & Vision ScienceDepartment of Ophthalmology & Vision SciencePurpose. Evaluate the relationship between retinal vascular caliber and age-related macular degeneration (AMD) severity or progression. Methods. A retrospective secondary analysis of 1172 fundus photographs and clinical data from the prospective Age-Related Eye Disease Study (AREDS). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole-to-venule ratio (AVR) were measured using the Parr–Hubbard–Knudtson formula. Univariate and multivariate regressions were used to determine the association of CRAE, CRVE, and AVR with age, sex, smoking status, presence of cilioretinal artery, and AMD severity at baseline and 5 years using the 9-step AMD severity score. Results. Only CRAE and CRVE were higher in men (P<0.001), current smokers (P<0.001), and the eyes with a cilioretinal artery (P=0.009−0.043). AMD severity was greater in older patients (P=0.001), current smokers (P=0.012), the eyes without a cilioretinal artery (P=0.001), and lower AVR (P=0.034) on multivariate regression but was not influenced by CRAE or CRVE (P=0.240−0.500). Choroidal neovascularization (CNV) presence was associated with older age (P=0.003) and absence of a cilioretinal artery (P=0.009), while central geographic atrophy (CGA) was associated with narrower CRAE (P=0.002) and possibly AVR (P=0.046). None of the retinal vessel parameters were predictive of AMD severity score or new onset of CNV or CGA at 5 years. Conclusion. A lower arteriole-to-venule ratio may be associated with AMD severity, with narrower arterioles seen in the eyes with geographic atrophy, suggesting a role of the retinal vasculature in AMD pathophysiology. This trial is registered with ClinicalTrials.gov Identifier: NCT00000145.http://dx.doi.org/10.1155/2022/8210599 |
| spellingShingle | Sara Toulouie Sean Chang Julia Pan Kiersten Snyder Glenn Yiu Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration Journal of Ophthalmology |
| title | Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration |
| title_full | Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration |
| title_fullStr | Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration |
| title_full_unstemmed | Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration |
| title_short | Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration |
| title_sort | relationship of retinal vessel caliber with age related macular degeneration |
| url | http://dx.doi.org/10.1155/2022/8210599 |
| work_keys_str_mv | AT saratoulouie relationshipofretinalvesselcaliberwithagerelatedmaculardegeneration AT seanchang relationshipofretinalvesselcaliberwithagerelatedmaculardegeneration AT juliapan relationshipofretinalvesselcaliberwithagerelatedmaculardegeneration AT kierstensnyder relationshipofretinalvesselcaliberwithagerelatedmaculardegeneration AT glennyiu relationshipofretinalvesselcaliberwithagerelatedmaculardegeneration |