Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis

Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis

Abstract In this multicenter study we investigated whether echocardiography-derived left ventricular global longitudinal strain (LV GLS), an indicator of myocardial fibrosis, independently predicts a positive genotype in hypertrophic cardiomyopathy (HCM). We performed a cross-sectional analysis incl...

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Main Authors: Viktoria Santner, Viktoria Höller, Maria Ungericht, Nora Schwegel, David Zach, Heidelis Tichy, Gert Waltl, Richard Belciug, Markus Wallner, Johannes Gollmer, Ewald Kolesnik, Peter P. Rainer, Dirk von Lewinski, Klemens Ablasser, Sabine Rudnik-Schöneborn, Gerhard Pölzl, Ellen Heitzer, Andreas Zirlik, Nicolas Verheyen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hypertrophic cardiomyopathy
Echocardiography
Strain
Myocardial fibrosis
Genetic testing
Genotype
Online Access:https://doi.org/10.1038/s41598-025-05696-5
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