Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance
Cancer drug resistance is a critical factor restricting the success rate of chemotherapeutics. Alterations in both cellular and systemic mechanisms could induce drug resistance in cancer. At the cellular level, numerous pathways have been associated with cancer drug resistance depending on the tumor...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-07-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/cyclooxygenases-and-lipoxygenases-in-cancer-drug-resistance/doi/gmj.2025.4388 |
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| author | Hasan Hüseyin Kazan Ahmet Çağlar Özketen Çağrı Urfalı Mamatoğlu |
| author_facet | Hasan Hüseyin Kazan Ahmet Çağlar Özketen Çağrı Urfalı Mamatoğlu |
| author_sort | Hasan Hüseyin Kazan |
| collection | DOAJ |
| description | Cancer drug resistance is a critical factor restricting the success rate of chemotherapeutics. Alterations in both cellular and systemic mechanisms could induce drug resistance in cancer. At the cellular level, numerous pathways have been associated with cancer drug resistance depending on the tumor origin and anti-cancer agent. Amongst other pathways including overexpression of multidrug resistance proteins, lipid modifier enzymes have also been linked to drug resistance in cancer via regulation of multidrug resistance protein levels, cell death mechanisms, and reactive lipid and oxygen species. Here the involvement of cyclooxygenases (COXs) and lipoxygenases (LOXs) as members of lipid modifier enzymes in cancer drug resistance should be emphasized. In this review, we summarize the studies examining the vital role of COXs/LOXs in the development and modulation of cancer drug resistance and cancer treatment. |
| format | Article |
| id | doaj-art-84bda5768f7d4543967faabd7c38087f |
| institution | DOAJ |
| issn | 2147-2092 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-84bda5768f7d4543967faabd7c38087f2025-08-20T02:40:33ZengGalenos Publishing HouseGazi Medical Journal2147-20922025-07-0136337638410.12996/gmj.2025.4388Cyclooxygenases and Lipoxygenases in Cancer Drug ResistanceHasan Hüseyin Kazan0https://orcid.org/0000-0001-7936-8606Ahmet Çağlar Özketen1https://orcid.org/0000-0001-6482-6918Çağrı Urfalı Mamatoğlu2https://orcid.org/0000-0001-7091-4770Department of Medical Biology, University of Health Sciences Türkiye, Gülhane Faculty of Medicine, Ankara, TürkiyeDESAM Research Institute, Near East University Faculty of Medicine, Nicosia, Northern Cyprus, TürkiyeDepartment of Biological Sciences, Middle East Technical University Faculty of Arts and Sciences, Ankara, TürkiyeCancer drug resistance is a critical factor restricting the success rate of chemotherapeutics. Alterations in both cellular and systemic mechanisms could induce drug resistance in cancer. At the cellular level, numerous pathways have been associated with cancer drug resistance depending on the tumor origin and anti-cancer agent. Amongst other pathways including overexpression of multidrug resistance proteins, lipid modifier enzymes have also been linked to drug resistance in cancer via regulation of multidrug resistance protein levels, cell death mechanisms, and reactive lipid and oxygen species. Here the involvement of cyclooxygenases (COXs) and lipoxygenases (LOXs) as members of lipid modifier enzymes in cancer drug resistance should be emphasized. In this review, we summarize the studies examining the vital role of COXs/LOXs in the development and modulation of cancer drug resistance and cancer treatment.https://gazimedj.com/articles/cyclooxygenases-and-lipoxygenases-in-cancer-drug-resistance/doi/gmj.2025.4388cyclooxygenaseslipoxygenasescancer drug resistance |
| spellingShingle | Hasan Hüseyin Kazan Ahmet Çağlar Özketen Çağrı Urfalı Mamatoğlu Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance Gazi Medical Journal cyclooxygenases lipoxygenases cancer drug resistance |
| title | Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance |
| title_full | Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance |
| title_fullStr | Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance |
| title_full_unstemmed | Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance |
| title_short | Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance |
| title_sort | cyclooxygenases and lipoxygenases in cancer drug resistance |
| topic | cyclooxygenases lipoxygenases cancer drug resistance |
| url | https://gazimedj.com/articles/cyclooxygenases-and-lipoxygenases-in-cancer-drug-resistance/doi/gmj.2025.4388 |
| work_keys_str_mv | AT hasanhuseyinkazan cyclooxygenasesandlipoxygenasesincancerdrugresistance AT ahmetcaglarozketen cyclooxygenasesandlipoxygenasesincancerdrugresistance AT cagrıurfalımamatoglu cyclooxygenasesandlipoxygenasesincancerdrugresistance |