Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison
Abstract Purpose To evaluate the staging performance of positron emission tomography/magnetic resonance imaging (PET/MRI) for confirmed esophageal cancer based on the TNM classification system as well as compare it to other alternative modalities (e.g., endoscopic ultrasonography (EUS), computed tom...
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BMC
2025-01-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01565-9 |
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| author | Alisa Mohebbi Saeed Mohammadzadeh Zahra Moradi Afshin Mohammadi Hossein Poustchi Seyed Mohammad Tavangar |
| author_facet | Alisa Mohebbi Saeed Mohammadzadeh Zahra Moradi Afshin Mohammadi Hossein Poustchi Seyed Mohammad Tavangar |
| author_sort | Alisa Mohebbi |
| collection | DOAJ |
| description | Abstract Purpose To evaluate the staging performance of positron emission tomography/magnetic resonance imaging (PET/MRI) for confirmed esophageal cancer based on the TNM classification system as well as compare it to other alternative modalities (e.g., endoscopic ultrasonography (EUS), computed tomography (CT), MRI, and PET/CT) in a full head-to-head manner. Methods Protocol was pre-registered a priori at ( http://osf.io/6qj5m/ ). We searched PubMed, Web of Science, Embase, and Cochrane Library for studies until September 10, 2024. The risk of bias was assessed using Modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Quality Assessment of Diagnostic Accuracy Studies–Comparative (QUADAS-C). The classification performance of PET/MRI in T, N, and M staging of esophageal cancer and resectability status were evaluated and compared to other relative modalities. Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) was used for certainty evaluation. Results Nine studies were included with 245 esophageal cancer patients. For T, N, and M staging, PET/MRI showed 9.1%, 2.0%, and 10.7% upstaging than the histopathological evaluation while these numbers were 19.4%, 12.4%, and 5.3% for downstaging. For direct comparison with PET/CT, PET/MRI showed 0.7% and 5.6% less downstaging and upstaging for N staging and 2.5% and 4.0% for M staging. As for predicting resectability status, pre-ADCmean and post-ADCmean were promising, unlike other parameters (i.e., ΔADCmean, pre-SUVmax, post-SUVmax, and ΔSUVmax). Conclusion With protocol adjustments, PET/MRI might be utilized in the future for preoperative staging of esophageal cancer. Clinical trial number N/A. |
| format | Article |
| id | doaj-art-84bd74f4cb864fecad2f269100e12e77 |
| institution | Kabale University |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj-art-84bd74f4cb864fecad2f269100e12e772025-02-02T12:47:53ZengBMCBMC Medical Imaging1471-23422025-01-0125111110.1186/s12880-025-01565-9Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparisonAlisa Mohebbi0Saeed Mohammadzadeh1Zahra Moradi2Afshin Mohammadi3Hossein Poustchi4Seyed Mohammad Tavangar5Universal Scientific Education and Research Network (USERN)Universal Scientific Education and Research Network (USERN)Universal Scientific Education and Research Network (USERN)Department of Radiology, Faculty of Medicine, Urmia University of Medical ScienceDigestive Disease Research Institute, Tehran University of Medical SciencesDepartment of Pathology, Dr. Shariati Hospital, Tehran University of Medical SciencesAbstract Purpose To evaluate the staging performance of positron emission tomography/magnetic resonance imaging (PET/MRI) for confirmed esophageal cancer based on the TNM classification system as well as compare it to other alternative modalities (e.g., endoscopic ultrasonography (EUS), computed tomography (CT), MRI, and PET/CT) in a full head-to-head manner. Methods Protocol was pre-registered a priori at ( http://osf.io/6qj5m/ ). We searched PubMed, Web of Science, Embase, and Cochrane Library for studies until September 10, 2024. The risk of bias was assessed using Modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Quality Assessment of Diagnostic Accuracy Studies–Comparative (QUADAS-C). The classification performance of PET/MRI in T, N, and M staging of esophageal cancer and resectability status were evaluated and compared to other relative modalities. Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) was used for certainty evaluation. Results Nine studies were included with 245 esophageal cancer patients. For T, N, and M staging, PET/MRI showed 9.1%, 2.0%, and 10.7% upstaging than the histopathological evaluation while these numbers were 19.4%, 12.4%, and 5.3% for downstaging. For direct comparison with PET/CT, PET/MRI showed 0.7% and 5.6% less downstaging and upstaging for N staging and 2.5% and 4.0% for M staging. As for predicting resectability status, pre-ADCmean and post-ADCmean were promising, unlike other parameters (i.e., ΔADCmean, pre-SUVmax, post-SUVmax, and ΔSUVmax). Conclusion With protocol adjustments, PET/MRI might be utilized in the future for preoperative staging of esophageal cancer. Clinical trial number N/A.https://doi.org/10.1186/s12880-025-01565-9Positron emission tomography (PET)Magnetic resonance imaging (MRI)PET/MRIPET/MREsophageal cancer |
| spellingShingle | Alisa Mohebbi Saeed Mohammadzadeh Zahra Moradi Afshin Mohammadi Hossein Poustchi Seyed Mohammad Tavangar Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison BMC Medical Imaging Positron emission tomography (PET) Magnetic resonance imaging (MRI) PET/MRI PET/MR Esophageal cancer |
| title | Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison |
| title_full | Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison |
| title_fullStr | Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison |
| title_full_unstemmed | Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison |
| title_short | Staging of esophageal cancer using PET/MRI: a systematic review with head-to-head comparison |
| title_sort | staging of esophageal cancer using pet mri a systematic review with head to head comparison |
| topic | Positron emission tomography (PET) Magnetic resonance imaging (MRI) PET/MRI PET/MR Esophageal cancer |
| url | https://doi.org/10.1186/s12880-025-01565-9 |
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